Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Midlands Health Data Research UK, University of Birmingham, Birmingham, UK.
J Neurol Neurosurg Psychiatry. 2024 Sep 17;95(10):938-946. doi: 10.1136/jnnp-2024-333530.
Migraine is common in women of reproductive age. This study aimed to (1) describe the prevalence of migraine in pregnant women in the UK, (2) identify drugs commonly prescribed for migraine during pregnancy and (3) identify characteristics associated with being prescribed medication for migraine during pregnancy.
The Clinical Practice Research Datalink pregnancy register, a database of pregnancy episodes identified in anonymised primary care health records, was used.Crude and age-standardised prevalence of migraine during pregnancy and the proportion of women with migraine prescribed drugs used for migraine management were calculated for each year between 2000 and 2018.Logistic regression was used to describe the relationship between patient characteristics and being prescribed migraine medication during pregnancy.
1 377 053 pregnancies were included, of which 187 328 were in women with a history of migraine. The age-adjusted prevalence increased from 11.4% in 2000 to 17.2% in 2018. There was an increase in the rates of prescription for numerous medications for the management of migraine.Older women (adjusted OR (aOR) 1.41 (1.20 to 1.66)), women of black (aOR 1.40 (1.32 to 1.48)) and South Asian ethnicity (aOR 1.48 (1.38 to 1.59)), those living in the most deprived areas (aOR 1.60 (1.54 to 1.66)), women who were obese (aOR 1.39 (1.35 to 1.43)), smokers (aOR 1.15 (1.12 to 1.18)) and those with comorbid conditions were more likely to receive a prescription during pregnancy.
Rates of recorded migraine have increased over the past two decades as well as rates of prescribing in women with migraine. Higher prescribing rates are seen in certain groups, which has the potential to exacerbate health inequalities.
偏头痛在育龄期女性中很常见。本研究旨在：（1）描述英国孕妇偏头痛的患病率；（2）确定怀孕期间常用于偏头痛的药物；（3）确定与怀孕期间开偏头痛药物相关的特征。
使用临床实践研究数据链接妊娠登记处，这是一个在匿名初级保健健康记录中识别妊娠事件的数据库。计算了 2000 年至 2018 年期间每年怀孕期间偏头痛的粗患病率和标准化患病率，以及患有偏头痛的女性中用于偏头痛管理的药物的比例。使用逻辑回归描述患者特征与怀孕期间开偏头痛药物之间的关系。
纳入了 1377053 例妊娠，其中 187328 例孕妇有偏头痛病史。年龄调整后的患病率从 2000 年的 11.4%增加到 2018 年的 17.2%。用于治疗偏头痛的多种药物的处方率有所增加。年龄较大的女性（调整后的比值比（aOR）为 1.41（1.20 至 1.66））、黑人和南亚裔女性（aOR 分别为 1.40（1.32 至 1.48）和 1.48（1.38 至 1.59））、生活在最贫困地区的女性（aOR 1.60（1.54 至 1.66））、肥胖的女性（aOR 1.39（1.35 至 1.43））、吸烟者（aOR 1.15（1.12 至 1.18））和合并症患者更有可能在怀孕期间开处方。
在过去的二十年中，记录的偏头痛发病率以及偏头痛女性的处方率都有所增加。某些群体的处方率更高，这有可能加剧健康不平等。
