Jiang Yuhan, Li Tenghai, Lou Yingyue, Liu Bingzhang, Liu Yilin, Li Tian, Zhang Duo
Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Rehabilitation, The Second Hospital of Jilin University, Changchun, 130022, China.
J Mater Sci Mater Med. 2024 Dec 30;36(1):1. doi: 10.1007/s10856-024-06852-5.
In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of the difficult problems for clinicians. The vigorous development of material science and tissue engineering provides new ideas for the treatment of OCD, in which the selection of scaffold materials is particularly important. In this study, true-bone-ceramics (TBC), which has good mechanical strength and osteoconductivity, and type I collagen (COL1), which has excellent biocompatibility, were chosen as scaffold materials to co-construct the TBC/COL1 scaffold for osteochondral repair. In order to ensure the most appropriate collagen coating concentration, three experimental groups (1, 5, 12 mg/ml) were set up. Through the physicochemical property test, biocompatibility analysis and in vivo implantation experiments of composite scaffolds, 12 mg/ml TBC/COL1 scaffolds present the best repair effect among the three groups.
近年来，软骨缺损的发病率急剧上升，其病因复杂多样。作为主要病因之一的剥脱性骨软骨炎（OCD），会对软骨和骨组织造成损害，并可能发展为严重的骨关节炎，这一直是临床医生面临的难题之一。材料科学和组织工程的蓬勃发展为OCD的治疗提供了新思路，其中支架材料的选择尤为重要。在本研究中，选择具有良好机械强度和骨传导性的真骨陶瓷（TBC）以及具有优异生物相容性的I型胶原蛋白（COL1）作为支架材料，共同构建用于骨软骨修复的TBC/COL1支架。为确保最合适的胶原蛋白涂层浓度，设置了三个实验组（1、5、12 mg/ml）。通过对复合支架进行理化性能测试、生物相容性分析和体内植入实验，12 mg/ml的TBC/COL1支架在三组中呈现出最佳的修复效果。
