Department of Orthopedics , China-Japan Union Hospital of Jilin University , 126 Xiantai Street , Changchun 130033 , P. R. China.
Knee Surgery Department of the Institute of Sports Medicine , Peking University Third Hospital , 49 Huayuanbei Road , Beijing 100191 , P. R. China.
Biomacromolecules. 2019 Apr 8;20(4):1478-1492. doi: 10.1021/acs.biomac.9b00043. Epub 2019 Mar 20.
Articular cartilage defects, caused by trauma, osteoarthritis, or other diseases, always lead to severe joint pain and joint dysfunction. Without access to progenitor cells and the supply of blood and nutrients, the impaired articular cartilage would be short of the capability to self-repair. Although the present clinical treatments, including autogenous and allograft osteochondral transplantation, microfracture technique, and so forth, have shown some efficacies, their drawbacks, such as donor insufficiency and poor-integration with adjacent tissue, limit the satisfactory repair of articular cartilage defects and cause unsatisfied prognosis. Cartilage tissue engineering, involving the combination of progenitor cells with scaffolds, which serve as artificial extracellular matrices (ECMs), provides a promising strategy for cartilage regeneration. Recently, thermosensitive hydrogels have attracted much attention as scaffolds for cartilage tissue engineering owing to their unique physical properties analogous to the native ECM. In this review, we summarize the fabrication, characterization of newly reported thermosensitive hydrogels as cartilage tissue engineering scaffolds. The potential challenges and future perspectives are proposed.
关节软骨缺损由创伤、骨关节炎或其他疾病引起，常导致严重的关节疼痛和关节功能障碍。由于缺乏祖细胞以及血液和营养物质的供应，受损的关节软骨会缺乏自我修复的能力。尽管目前的临床治疗方法，包括自体和同种异体骨软骨移植、微骨折技术等，已经显示出一定的疗效，但它们存在供体不足和与邻近组织结合不良等缺点，限制了关节软骨缺损的满意修复，并导致预后不佳。软骨组织工程将祖细胞与支架结合，支架作为人工细胞外基质（ECM），为软骨再生提供了一种很有前途的策略。最近，由于具有类似于天然 ECM 的独特物理性质，温敏水凝胶作为软骨组织工程支架引起了广泛关注。本文综述了新型温敏水凝胶作为软骨组织工程支架的制备和表征。提出了潜在的挑战和未来展望。
