Hinad Ibrahim, S'hih Youssef, Mesfioui Abdelhalem, Elhessni Aboubaker, Ouahidi Moulay Laarbi
Laboratory of Biology and Health, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Plant Foods Hum Nutr. 2024 Dec 30;80(1):23. doi: 10.1007/s11130-024-01276-6.
Trigonella foenum-graecum L. (fenugreek) seeds are widely used in the preparation of various meals and in traditional health care to treat various disorders and diseases, especially Diabetes mellitus. This study was conducted to investigate the antihyperglycemic and antihyperlipidemic effects of the fenugreek seed extract on fructose-induced diabetic wistar rats. Indeed, 5 groups of rats were formed; the first and second groups were composed of normal rats treated with distilled water and fenugreek seed extract, respectively. The third, fourth, and fifth groups composed of diabetic rats were administered distilled water, 500 mg/kg of fenugreek seed extract, and 25 µg/kg. bw of a standard antidiabetic drug consecutively for 28 days. The repeated ingestion of fenugreek seed generated a significant rise (p < 0.05) of food and water consumption in diabetic rats as compared to the rats treated with distilled water. Furthermore, fenugreek seed extract caused a remarkable elevation of the body weights of diabetic rats in comparison with other groups. Additionally, chronic treatment of rats with fenugreek seed extract improved fasting blood sugar, total cholesterol and triglycerides levels in diabetic rats. Fenugreek seed extract has significant anti-diabetic activity by reducing the fasting blood sugar and ameliorating the lipid parameters of diabetic rats. However, more studies are required to isolate the phytochemical constituents that possess these activities and elucidate their mechanisms of action.
胡芦巴（Trigonella foenum - graecum L.）种子广泛用于各种膳食的制备以及传统医疗保健中，以治疗各种病症和疾病，尤其是糖尿病。本研究旨在调查胡芦巴种子提取物对果糖诱导的糖尿病Wistar大鼠的降血糖和降血脂作用。实际上，实验将大鼠分为5组；第一组和第二组分别由用蒸馏水和胡芦巴种子提取物处理的正常大鼠组成。第三组、第四组和第五组由糖尿病大鼠组成，它们分别连续28天给予蒸馏水、500 mg/kg的胡芦巴种子提取物和25 μg/kg体重的标准抗糖尿病药物。与用蒸馏水处理的大鼠相比，糖尿病大鼠反复摄入胡芦巴种子后，其食物和水的消耗量显著增加（p < 0.05）。此外，与其他组相比，胡芦巴种子提取物使糖尿病大鼠的体重显著增加。此外，用胡芦巴种子提取物对大鼠进行长期治疗可改善糖尿病大鼠的空腹血糖、总胆固醇和甘油三酯水平。胡芦巴种子提取物通过降低空腹血糖和改善糖尿病大鼠的脂质参数而具有显著的抗糖尿病活性。然而，需要更多的研究来分离具有这些活性的植物化学成分并阐明其作用机制。
