Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.
Institute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, Poland.
Nutrients. 2020 Aug 24;12(9):2552. doi: 10.3390/nu12092552.
Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant ( < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.
葫芦巴籽在亚洲和世界其他地区因其营养和药用特性而被广泛使用。在亚洲，葫芦巴籽也被推荐给老年人群体。在这里，我们首次评估了葫芦巴籽饲料补充对衰老小鼠肝脏抗氧化防御系统的影响。该研究在 12 个月大的给予葫芦巴籽饮食补充的小鼠上进行。我们评估了各种抗氧化防御酶的活性，如超氧化物歧化酶（SOD）、谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GPx），并在给予葫芦巴籽后估计了小鼠肝脏中的酚类物质和自由基清除特性。在年老小鼠肝脏中对 SOD、GPx 和 GR 活性的测定显示所有肝脏酶之间存在显著差异（<0.01）。总的来说，这项研究表明，葫芦巴籽饮食补充对老年小鼠肝脏抗氧化防御酶的活性有积极影响。
