Ruan Zhishen, Li Dan, Cong Xiaodong, Yuan Shasha, Fan Yiling, Xu Bo, Miao Qing
Xiyuan Hospital of Chinese Academy of Chinese Medical Sciences, Beijing, China.
Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Aging Clin Exp Res. 2024 Dec 30;37(1):17. doi: 10.1007/s40520-024-02905-5.
As ageing accelerates, frailty increasingly impacts public health. Cough, sputum, wheezing and dyspnea are common respiratory symptoms, and the relationship to frailty is unclear. We aimed to analyze the relationship between respiratory symptoms and frailty.
Cross-sectional and Mendelian randomization (MR) studies were used. Cross-sectional data involved 14,021 participants from the National Health and Nutrition Examination Survey (NHANES). Logistic and linear regression were used to analyze the relationship between respiratory symptoms (cough, sputum, wheezing, dyspnea) and frailty. We adjusted for multiple variables and used propensity score matching (PSM). Mediation analysis was used to explore the role of inflammatory markers and age in the relationship between the two. We analyzed the relationship using a two-sample MR approach with data from genome-wide association studies (GWAS) to enhance causal inference.
Observational studies have shown that cough (OR 1.74, 95 CI% 1.44, 2.09), sputum (OR 1.87, 95 CI% 1.57, 2.22), wheezing (OR 2.01, 95 CI% 1.68, 2.40), and dyspnea (OR 2.60, 95 CI% 2.28, 2.97) are associated with an elevated risk of frailty. The PSM results were stable. Mediation analyses indicated that elevated inflammatory markers and advancing age were mediators between respiratory symptoms and frailty. The results of the MR study showed that sputum and wheezing were associated with an elevated frailty index; and in the study of FI on respiratory symptoms, all respiratory symptoms were elevated with elevated FI.
Our study identified a potential association between frailty and respiratory symptoms. Inflammation and ageing may be essential factors mediating this association.
随着老龄化加速，衰弱对公众健康的影响日益增大。咳嗽、咳痰、喘息和呼吸困难是常见的呼吸道症状，其与衰弱的关系尚不清楚。我们旨在分析呼吸道症状与衰弱之间的关系。
采用横断面研究和孟德尔随机化（MR）研究。横断面数据来自国家健康与营养检查调查（NHANES）的14021名参与者。采用逻辑回归和线性回归分析呼吸道症状（咳嗽、咳痰、喘息、呼吸困难）与衰弱之间的关系。我们对多个变量进行了调整，并使用了倾向得分匹配（PSM）。中介分析用于探讨炎症标志物和年龄在两者关系中的作用。我们使用两样本MR方法和全基因组关联研究（GWAS）的数据进行分析，以加强因果推断。
观察性研究表明，咳嗽（比值比1.74，95%置信区间1.44，2.09）、咳痰（比值比1.87，95%置信区间1.57，2.22）、喘息（比值比2.01，95%置信区间1.68，2.40）和呼吸困难（比值比2.60，95%置信区间2.28，2.97）与衰弱风险升高相关。PSM结果稳定。中介分析表明，炎症标志物升高和年龄增长是呼吸道症状与衰弱之间的中介因素。MR研究结果表明，咳痰和喘息与衰弱指数升高相关；在关于衰弱指数对呼吸道症状影响的研究中，所有呼吸道症状均随衰弱指数升高而增加。
我们的研究确定了衰弱与呼吸道症状之间的潜在关联。炎症和衰老可能是介导这种关联的重要因素。
