The HIV incidence rate continues to increase among youth, especially among young men who have sex with men (YMSM) and young transgender women (YTW). To date, behavioral intention has often been viewed as the likelihood of engaging in prevention behaviors and emphasized as a key antecedent for condom use, disclosure of serostatus, and PrEP use among people living with HIV. In addition, individuals with different sociodemographic factors may have varying degrees of HIV prevention intention, which is a critical knowledge needed to identify facilitators and barriers to HIV prevention intention. This is a secondary data analysis of baseline data from a randomized controlled trial (RCT) (N = 488). This study aimed to identify distinct, latent classes of HIV prevention intention among youth vulnerable to HIV acquisition and to understand the sociodemographic and contextual factors associated with each latent class. Latent class analysis was conducted to identify meaningful latent classes of youths based on HIV prevention intention. Class 1: "High condomless sex, low serosorting, low PrEP intention," Class 2: "High condomless sex, high serosorting, low PrEP intention," Class 3: "Moderate condom use, serosorting, low PrEP intention," and Class 4: "Moderate condom use, high serosorting, moderate PrEP intention" were identified. Significant differences were found in age, sexual orientation, level of education, current employment status, annual household income, housing/living arrangement, and relationship status. Overall, YMSM and YTW without a recent history of HIV testing or PrEP use may have particularly low intentions for HIV prevention, and therefore may be at higher risk for HIV infection.