Yan Wenjun, Xu Di, Duan Qiongli, Huang Nengmei, Han Jing, Shi Yuhua, Li Jian, Liu Hongjie
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People's Republic of China.
AIDS Behav. 2025 Apr;29(4):1281-1293. doi: 10.1007/s10461-024-04602-w. Epub 2024 Dec 30.
Due to limited data on the determinants of HIV care continuum outcomes among people living with HIV (PLWH) in resource-limited settings, this study aimed to identify individual and social support network factors influencing these outcomes, thereby informing the development of intervention strategies to achieve the UNAIDS 95-95-95 targets. PLWH in Yunnan, China, were recruited using convenience sampling at three stages of the HIV care continuum: linkage to care, antiretroviral therapy (ART) initiation, and viral suppression. An egocentric network design combined with multilevel logit modeling was employed to investigate factors associated with ART initiation and viral suppression. A total of 410 eligible participants were recruited into the study. Of these, 145 (35.4%) were linked to care but did not initiate ART, 265 (64.6%) initiated ART, and 131 (49.4%) achieved viral suppression. Higher trust in alters, larger network density, stronger social support, and longer ego-alter relationship were positively associated with ART initiation and viral suppression. Participants who received social support from friends or family members had higher odds of initiating ART compared to those who received support from sexual partners. Factors associated with viral suppression were larger network size, having older alters and alters with higher education in an ego's social support network. The findings enhance our understanding of how social support network determinants influence HIV care continuum outcomes. Interventions for PLWH in China should consider these social support network characteristics to improve outcomes.
由于资源有限环境下感染艾滋病毒者(PLWH)中艾滋病毒治疗连续结果的决定因素数据有限,本研究旨在确定影响这些结果的个人和社会支持网络因素,从而为实现联合国艾滋病规划署95-95-95目标的干预策略制定提供信息。在中国云南,通过便利抽样在艾滋病毒治疗连续的三个阶段招募PLWH:与护理的联系、抗逆转录病毒疗法(ART)启动和病毒抑制。采用以自我为中心的网络设计结合多层次逻辑模型来研究与ART启动和病毒抑制相关的因素。共有410名符合条件的参与者被纳入研究。其中,145人(35.4%)与护理建立了联系但未启动ART,265人(64.6%)启动了ART,131人(49.4%)实现了病毒抑制。对 alters 的更高信任、更大的网络密度、更强的社会支持以及更长的自我与 alters 的关系与ART启动和病毒抑制呈正相关。与从性伴侣获得支持的参与者相比,从朋友或家庭成员获得社会支持的参与者启动ART的几率更高。与病毒抑制相关的因素包括更大的网络规模、在自我的社会支持网络中有年龄较大的 alters 以及受过高等教育的 alters。这些发现增强了我们对社会支持网络决定因素如何影响艾滋病毒治疗连续结果的理解。中国针对PLWH的干预措施应考虑这些社会支持网络特征以改善结果。