Cox Sarah E, Cattaneo Giulia, Russell Oliver, McGregor Ombeline, Kortum Andre
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Vet Med Sci. 2025 Jan;11(1):e70188. doi: 10.1002/vms3.70188.
A 12-year-old terrier was referred for investigation of a 4-month history of coughing, sneezing and nasal discharge. Clinical findings were consistent with sinonasal Aspergillus fumigatus infection with evidence of intracranial extension on computed tomography. Endoscopic debridement followed by topical clotrimazole and systemic antifungal therapy resulted in clinical improvement. Magnetic resonance imaging after 4 weeks showed reduced intracranial disease but demonstrated evidence of temporal myositis. Repeated debridement and topical treatment were performed at 4 and 8 weeks in conjunction with long-term voriconazole therapy. Further interventions were declined; the dog remains clinically well after 4 months with unilateral nasal discharge. As in human patients, invasive subtypes of sinonasal aspergillosis may also occur in dogs and be associated with poorer response to treatment.
一只12岁的梗犬因咳嗽、打喷嚏和流鼻涕4个月的病史被转诊进行检查。临床检查结果与鼻窦烟曲霉感染相符，计算机断层扫描显示有颅内扩展的迹象。内镜清创术，随后局部使用克霉唑和全身抗真菌治疗，使临床症状得到改善。4周后的磁共振成像显示颅内疾病有所减轻，但有颞肌炎的迹象。在第4周和第8周重复进行清创术和局部治疗，并结合长期伏立康唑治疗。进一步的干预措施被拒绝；这只狗在4个月后仍有单侧流鼻涕，但临床状况良好。与人类患者一样，鼻窦曲霉病的侵袭性亚型也可能发生在犬类中，并且与对治疗的反应较差有关。
