Bellegarda Celine, Auer Franziska, Schoppik David
Departments of Otolaryngology, Neuroscience, and the Neuroscience Institute, NYU Grossman School of Medicine, USA.
Departments of Otolaryngology, Neuroscience, and the Neuroscience Institute, NYU Grossman School of Medicine, USA.
Curr Opin Neurobiol. 2025 Feb;90:102964. doi: 10.1016/j.conb.2024.102964. Epub 2024 Dec 30.
Motor neurons have highly diverse anatomical, functional and molecular features, and differ significantly in their susceptibility in disease. Extraocular motor neurons, residing in the oculomotor, trochlear and abducens cranial nuclei (nIII, nIV and nVI), control eye movements. Recent work has begun to clarify the developmental mechanisms by which functional diversity among extraocular motor neurons arises. However, we know little about the role and consequences of extraocular motor neuron diversity in eye movement control. Here, we highlight recent work investigating the anatomical, functional and molecular features of extraocular motor neurons. Further, we frame hypotheses where studying ocular motor circuits in the larval zebrafish is poised to illuminate the consequences of motor neuron diversity for behavior.
运动神经元具有高度多样的解剖学、功能和分子特征，并且在疾病易感性方面存在显著差异。位于动眼神经、滑车神经和展神经颅神经核（第III、IV和VI神经核）中的眼球外运动神经元控制眼球运动。最近的研究开始阐明眼球外运动神经元之间功能多样性产生的发育机制。然而，我们对眼球外运动神经元多样性在眼球运动控制中的作用和后果知之甚少。在这里，我们重点介绍了最近关于研究眼球外运动神经元的解剖学、功能和分子特征的工作。此外，我们提出了一些假设，即在幼体斑马鱼中研究眼球运动回路有望阐明运动神经元多样性对行为的影响。
