Marc-Antoine Migaud, Simon Henry
CHU de Lille, 2 Avenue Oscar Lambret, Hauts-de-France, France.
Clin Neurol Neurosurg. 2025 Feb;249:108707. doi: 10.1016/j.clineuro.2024.108707. Epub 2024 Dec 25.
Spontaneous intracranial hypotension (SIH) is a secondary cause of headache. Its pathophysiology is complex, and relies mainly on the notion of a localized leak, and thus a loss of cerebrospinal fluid (CSF) in the spinal region. SIH is little known to the medical profession, for which CT myelography is a technique on the rise, allowing to identify and treat the leak using a blood-patch or a fibrin sealant. The aim of the study was to investigate the contribution of CT myelography in the diagnostic and therapeutic management of spontaneous intracranial hypotension, its modalities and population characteristics.
A cohort of patients with spontaneous intracranial hypotension who underwent a CT myelography in our department was retrospectively studied. Nineteen patients were included between March 2020 and October 2022.
CT myelography allowed identification of an etiology in 16 patients (84 %). The etiology of the leak was mainly a dural tear, identified in 11 patients. One diverticulum and 4 CSF-venous fistulas were identified. First targeted injection of fibrin sealant allowed stopped the leak in 12 out of 17 patients.
CT myelography allows to identify the etiology of the CSF leak and pinpoint its topography. CT guidance can then be used to treat the leak in the same therapeutic timeframe, with greater efficacy during the first targeted injection of fibrin sealant. The current study data showed a high incidence of dural tears, and a significant proportion of venous-dural fistulas, and a low incidence of diverticulum.
自发性颅内低压(SIH)是头痛的继发原因。其病理生理学复杂,主要基于局部渗漏的概念,即脊髓区域脑脊液(CSF)的流失。医学专业人员对SIH了解甚少,CT脊髓造影是一种正在兴起的技术,可通过血液补片或纤维蛋白密封剂来识别和治疗渗漏。本研究的目的是探讨CT脊髓造影在自发性颅内低压的诊断和治疗管理中的作用、方式及人群特征。
回顾性研究了在我科接受CT脊髓造影的自发性颅内低压患者队列。纳入了2020年3月至2022年10月期间的19例患者。
CT脊髓造影使16例患者(84%)明确了病因。渗漏的主要病因是硬脑膜撕裂,11例患者中发现。还发现1个憩室和4例脑脊液静脉瘘。首次靶向注射纤维蛋白密封剂使17例患者中的12例渗漏停止。
CT脊髓造影可识别脑脊液渗漏的病因并确定其位置。然后可在同一治疗时间范围内使用CT引导治疗渗漏,首次靶向注射纤维蛋白密封剂时疗效更佳。本研究数据显示硬脑膜撕裂发生率高,静脉 - 硬脑膜瘘比例显著,憩室发生率低。