Blyth Mark J G, Clement Nick D, Choo Xin Y, Doonan James, MacLean Angus, Jones Bryn G
Department of Trauma and Orthopaedics, Glasgow Royal Infirmary, Glasgow, UK.
Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, Edinburgh, UK.
Bone Joint J. 2025 Jan 1;107-B(1):72-80. doi: 10.1302/0301-620X.107B1.BJJ-2024-0245.R2.
The aim of this study was to perform an incremental cost-utility analysis and assess the impact of differential costs and case volume on the cost-effectiveness of robotic arm-assisted medial unicompartmental knee arthroplasty (rUKA) compared to manual (mUKA).
Ten-year follow-up of patients who were randomized to rUKA (n = 64) or mUKA (n = 65) was performed. Patients completed the EuroQol five-dimension health questionnaire preoperatively, at three months, and one, two, five, and ten years postoperatively, which was used to calculate quality-adjusted life years (QALY) gained and the incremental cost-effectiveness ratio (ICER). Costs for the index and additional surgery and healthcare costs were calculated.
mUKA had a lower survival for reintervention (84.8% (95% CI 76.2 to 93.4); p = 0.001), all-cause revision (88.9% (95% CI 81.3 to 96.5); p = 0.007) and aseptic revision (91.9% (95% CI 85.1 to 98.7); p = 0.023) when compared to the rUKA group at ten years, which was 100%. The rUKA group had a greater QALY gain per patient (mean difference 0.186; p = 0.651). Overall rUKA was the dominant intervention, being cost-saving and more effective with a greater health-related quality of life gain. On removal of infected reinterventions (n = 2), the ICER was £757 (not discounted) and £481 (discounted). When including all reintervention costs, rUKA was cost-saving when more than 100 robotic cases were performed per year. When removing the infected cases, rUKA was cost-saving when undertaking more than 800 robotic cases per year.
rUKA had lower reintervention and revision risks at ten years, which was cost-saving and associated with a greater QALY gain, and was the dominant procedure. When removing the cost of infection, which could be a random event, rUKA was a cost-effective intervention with an ICER (£757) which was lower than the willingness-to-pay threshold (£20,000).
本研究旨在进行增量成本-效用分析,并评估与手动单髁膝关节置换术(mUKA)相比,不同成本和病例数量对机器人手臂辅助内侧单髁膝关节置换术(rUKA)成本效益的影响。
对随机分配接受rUKA(n = 64)或mUKA(n = 65)的患者进行了为期十年的随访。患者在术前、术后三个月、一年、两年、五年和十年完成了欧洲五维健康问卷,用于计算获得的质量调整生命年(QALY)和增量成本效益比(ICER)。计算了初次手术和额外手术的成本以及医疗保健成本。
与十年时rUKA组100%的生存率相比,mUKA组再次干预的生存率较低(84.8%(95%CI 76.2至93.4);p = 0.001),全因翻修的生存率较低(88.9%(95%CI 81.3至96.5);p = 0.007),无菌翻修的生存率较低(91.9%(95%CI 85.1至98.7);p = 0.023)。rUKA组每位患者获得的QALY增益更大(平均差异0.186;p = 0.651)。总体而言,rUKA是主要干预措施,具有成本节约且更有效,健康相关生活质量增益更大。去除感染性再次干预(n = 2)后,ICER为757英镑(未贴现)和481英镑(贴现)。当包括所有再次干预成本时,每年进行超过100例机器人手术时,rUKA具有成本节约效果。去除感染病例后,每年进行超过800例机器人手术时,rUKA具有成本节约效果。
rUKA在十年时再次干预和翻修风险较低,具有成本节约效果且与更大的QALY增益相关,是主要手术方式。去除可能是随机事件的感染成本后,rUKA是一种具有成本效益的干预措施,ICER(757英镑)低于支付意愿阈值(20,000英镑)。