Gao Yan, Huang Yanzhao, Guo Kaiyun, Cheng Jun, Luo Yuting, Deng Yi, Lei Ming
The First People's Hospital of Changde City, Changde, Hunan, China.
Hengyang Medical College, Hengyang, Hunan, China.
J Med Genet. 2025 Feb 26;62(3):152-159. doi: 10.1136/jmg-2024-110437.
tsRNA is a class of non-coding RNAs derived from mature or precursor tRNAs. In recent years, more and more studies have explored the correlation between tsRNAs and tumours. tsRNAs can affect the biological behaviours of tumour cells such as proliferation, apoptosis and metastasis by regulating gene expression, protein translation or post-transcriptional regulation. In this paper, we systematically review the production, biological function and research progress of tsRNA in tumour and discuss its prospects as biomarkers and therapeutic targets.
tsRNA是一类从成熟或前体tRNA衍生而来的非编码RNA。近年来,越来越多的研究探讨了tsRNA与肿瘤之间的相关性。tsRNA可通过调节基因表达、蛋白质翻译或转录后调控来影响肿瘤细胞的生物学行为,如增殖、凋亡和转移。在本文中,我们系统地综述了tsRNA在肿瘤中的产生、生物学功能及研究进展,并讨论了其作为生物标志物和治疗靶点的前景。