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全球牙科感染控制中的生物工程创新:临床环境中的应用与适应

Bioengineering Innovations in Global Dental Infection Control: Applications and Adaptations in Clinical Settings.

作者信息

AlSaiari Abdullah Khalid Amer, Alonazi Mohammad S, Alotaibi Nasser Muneer, AlQahtani Hamad, Alotaibi Waleed Masoud, Yhyha Awatef Sliman Saleh Al, Aldarorah Aqilah, Alaklabi Nawal Megad, Al-Obayli Thuraya Ahmed Saleh, Alsaud Ohoud Abdulhadi Salha, Alosaimi Latifa Abdulrahman, Beshi Manal Ghazi Al

机构信息

King Salman Hospital, Ministry of Health, Riyadh, Saudi Arabia.

King Salman Hospital, Ministry of Health, Riyadh, Saudi Arabia.

出版信息

Int Dent J. 2025 Jun;75(3):2222-2238. doi: 10.1016/j.identj.2024.12.011. Epub 2024 Dec 30.

Abstract

INTRODUCTION AND AIMS

Dental practices pose a high risk of microbial contamination due to frequent exposure to bodily fluids like saliva and blood. Bioengineering innovations have emerged as vital tools to enhance infection control in dental settings. This review aims to assess the global applications and effectiveness of these innovations, particularly focusing on antimicrobial biomaterials, sterilization techniques, and personal protective equipment (PPE).

METHODS

A systematic review was conducted across major databases to identify studies from 2000 to 2024 that examined bioengineering technologies used in dental infection control. Inclusion criteria included studies focusing on antimicrobial materials, PPE, or novel sterilization technologies. Data extraction followed PRISMA guidelines, focusing on study design, dental settings, and clinical outcomes related to infection control.

RESULTS

Nine studies met the inclusion criteria, covering diverse geographical regions, including Italy, Saudi Arabia, Brazil, and India. Antimicrobial agents like silver and zinc oxide nanoparticles, UV-C sterilization, and low-temperature plasma were found to significantly reduce microbial contamination. The pooled effect size across studies was 1.62 (95% CI: 1.41-1.82) with low heterogeneity (I² = 6.4%). However, barriers such as high costs and limited resource availability were highlighted, particularly in lower-income regions.

CONCLUSION

Bioengineering innovations show significant potential for enhancing infection control in dental settings worldwide. While the technologies offer improved safety and hygiene, challenges related to cost and accessibility persist. Further research is needed to explore cost-effective and scalable solutions, particularly in resource-limited settings.

CLINICAL RELEVANCE

The integration of bioengineering technologies in dental practices can significantly improve infection control measures, reducing microbial contamination and enhancing safety for both patients and healthcare workers. These innovations hold promise for global adaptation, particularly in response to emerging public health challenges.

摘要

引言与目的

由于频繁接触唾液和血液等体液,牙科诊疗操作存在较高的微生物污染风险。生物工程创新已成为加强牙科环境感染控制的重要工具。本综述旨在评估这些创新在全球的应用情况及其有效性,尤其关注抗菌生物材料、消毒技术和个人防护装备(PPE)。

方法

在各大数据库中进行了系统综述,以识别2000年至2024年期间研究牙科感染控制中使用的生物工程技术的研究。纳入标准包括专注于抗菌材料、个人防护装备或新型消毒技术的研究。数据提取遵循PRISMA指南,重点关注研究设计、牙科环境以及与感染控制相关的临床结果。

结果

九项研究符合纳入标准,涵盖了不同的地理区域,包括意大利、沙特阿拉伯、巴西和印度。发现银和氧化锌纳米颗粒等抗菌剂、紫外线C消毒和低温等离子体可显著减少微生物污染。各研究的合并效应量为1.62(95%CI:1.41 - 1.82),异质性较低(I² = 6.4%)。然而,突出了高成本和资源可用性有限等障碍,特别是在低收入地区。

结论

生物工程创新在全球范围内加强牙科环境感染控制方面显示出巨大潜力。虽然这些技术提高了安全性和卫生水平,但与成本和可及性相关的挑战仍然存在。需要进一步研究以探索具有成本效益且可扩展的解决方案,特别是在资源有限的环境中。

临床意义

将生物工程技术整合到牙科诊疗操作中可显著改善感染控制措施,减少微生物污染,提高患者和医护人员的安全性。这些创新有望在全球得到应用,特别是应对新出现的公共卫生挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c18b/12142762/2cb846eb2764/gr1.jpg

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