Hua Tianzhen, Yao Fenghua, Wang Haitao, Liu Wei, Zhu Xiaomei, Yao Yongming
Department of Burns and Plastic Surgery, The Fourth Medical Center, Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing, 100048, China.
Chinese PLA Medical School, Beijing, 100853, China.
Crit Care. 2024 Dec 31;28(1):442. doi: 10.1186/s13054-024-05221-6.
Megakaryocytes are traditionally recognized as cells responsible for platelet production. However, beyond their role in thrombopoiesis, megakaryocytes also participate in inflammatory responses and regulate immune system functions. Sepsis, characterized by life-threatening organ dysfunction due to a dysregulated response to infection, prominently features coagulopathy, severe inflammation, and immune dysfunction as key pathophysiological aspects.
Given the diverse functions of megakaryocytes, we explore their roles in coagulation in the context of sepsis, and also in inflammatory and immune regulation. We try to infer future research directions and potential strategies for sepsis prevention and treatment based on the properties of megakaryocytes.
The purpose of this review is to both highlight and provide an update on the functions of megakaryocytes and pathophysiological changes in sepsis. Specific emphasis is given to the role of megakaryocytes in sepsis, which suggests value of future research and clinical application.
巨核细胞传统上被认为是负责血小板生成的细胞。然而，除了在血小板生成中的作用外，巨核细胞还参与炎症反应并调节免疫系统功能。脓毒症的特征是由于对感染的反应失调而导致危及生命的器官功能障碍，其主要病理生理方面包括凝血病、严重炎症和免疫功能障碍。
鉴于巨核细胞的多种功能，我们探讨它们在脓毒症背景下的凝血作用，以及在炎症和免疫调节中的作用。我们试图根据巨核细胞的特性推断脓毒症预防和治疗的未来研究方向和潜在策略。
本综述的目的是突出并更新巨核细胞的功能以及脓毒症中的病理生理变化。特别强调巨核细胞在脓毒症中的作用，这提示了未来研究和临床应用的价值。
