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巨核细胞和血小板在肺损伤中的研究进展。

Research progress of megakaryocytes and platelets in lung injury.

机构信息

Department of Burns and Plastic Surgery, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.

Medical School of Chinese PLA, Beijing, China.

出版信息

Ann Med. 2024 Dec;56(1):2362871. doi: 10.1080/07853890.2024.2362871. Epub 2024 Jun 20.

DOI:10.1080/07853890.2024.2362871
PMID:38902986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11195464/
Abstract

The lung is an important site of extramedullary platelet formation, and megakaryocytes in the lung participate in immune responses in addition to platelet production. In acute lung injury and chronic lung injury, megakaryocytes and platelets play a promoting or protective role through different mechanisms. The authors reviewed the role of megakaryocytes and platelets in common clinical lung injuries with different course of disease and different pathogenic factors in order to provide new thinking for the diagnosis and treatment of lung injuries.

摘要

肺是骨髓外血小板形成的重要部位，肺中的巨核细胞除了参与血小板生成外，还参与免疫反应。在急性肺损伤和慢性肺损伤中，巨核细胞和血小板通过不同的机制发挥促进或保护作用。作者回顾了巨核细胞和血小板在常见临床肺部损伤中的作用，这些损伤具有不同的病程和不同的致病因素，以期为肺部损伤的诊断和治疗提供新的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f3/11195464/446797d8563c/IANN_A_2362871_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f3/11195464/8bd630d8bddf/IANN_A_2362871_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f3/11195464/446797d8563c/IANN_A_2362871_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f3/11195464/8bd630d8bddf/IANN_A_2362871_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56f3/11195464/446797d8563c/IANN_A_2362871_F0002_C.jpg

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Epigenetic programming defines haematopoietic stem cell fate restriction.表观遗传编程定义了造血干细胞命运的限制。
Nat Cell Biol. 2023 Jun;25(6):812-822. doi: 10.1038/s41556-023-01137-5. Epub 2023 May 1.
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Emerging data on thrombopoietin receptor agonists for management of chemotherapy-induced thrombocytopenia.
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Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation.卷曲酮通过抑制血小板介导的中性粒细胞胞外诱捕网形成来改善脓毒症引起的肺损伤。
Int Immunopharmacol. 2023 May;118:110082. doi: 10.1016/j.intimp.2023.110082. Epub 2023 Mar 28.
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Acta Histochem. 2023 Apr;125(3):152024. doi: 10.1016/j.acthis.2023.152024. Epub 2023 Mar 21.
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