Gong Yi, Xue Qunhang, Li Jun, Zhang Shicui
Shanxi Key Laboratory of Birth Defect and Cell Regeneration, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China.
Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences, Kashi University, Kashi, China.
Front Microbiol. 2024 Dec 17;15:1511461. doi: 10.3389/fmicb.2024.1511461. eCollection 2024.
In the post-COVID-19 era, people are increasingly concerned about microbial infections, including fungal infections that have risen in recent years. However, the currently available antifungal agents are rather limited. Worse still, the widespread use of the antifungal agents has caused the emergence of antifungal resistance in , , and species. Therefore, the development of novel antifungals is urgently needed. Antimicrobial peptides (AMPs), as components of the first-line defense of the host, are found to exhibit broad antimicrobial activity against bacteria, fungi, parasites, viruses, and protozoa. AMPs with antifungal activity are specifically referred to as antifungal peptides (AFPs). AFPs are currently regarded as the most promising alternative to conventional antifungal agents due to the fact that they are highly selective and less prone to facilitate the selection of drug resistance. In this review, we present an overview of the origin and classification of natural AFPs as well as their modes of action. Additionally, the production of natural, semisynthetic, and synthetic AFPs with a view to greater levels of exploitation is discussed. Finally, we evaluate the current and potential applications of AFPs in clinics and in the food industry.
在新冠疫情后的时代，人们越来越关注微生物感染，包括近年来有所增加的真菌感染。然而，目前可用的抗真菌药物相当有限。更糟糕的是，抗真菌药物的广泛使用已导致在[此处可能缺失具体物种信息]物种中出现抗真菌耐药性。因此，迫切需要开发新型抗真菌药物。抗菌肽（AMPs）作为宿主一线防御的组成部分，被发现对细菌、真菌、寄生虫、病毒和原生动物具有广泛的抗菌活性。具有抗真菌活性的抗菌肽被特别称为抗真菌肽（AFPs）。由于AFPs具有高度选择性且不易促进耐药性的产生，目前它们被视为传统抗真菌药物最有前景的替代品。在本综述中，我们概述了天然AFPs的起源、分类及其作用方式。此外，还讨论了为实现更高水平的开发而生产天然、半合成和合成AFPs的情况。最后，我们评估了AFPs在临床和食品工业中的当前及潜在应用。
