Alsuwayt Bader, Iftikhar Neelam, Hussain Abdullah Ijaz, Ahmad Ashfaq, Zafar Irsa, Khanam Arifa, Tan Wen-Nee, Nahar Lutfun, Almuqati Afaf F, Haji Esraa Mohammad, Almutairy Ali F, Sarker Satyajit D
Department of Pharmacy Practice, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan.
Cardiovasc Ther. 2024 Oct 4;2024:3833521. doi: 10.1155/2024/3833521. eCollection 2024.
The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD). The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed-phase high-performance liquid chromatography (RP-HPLC). Two specific doses of MPT, namely, 250 and 500 mg/kg body weight (BW), were chosen for the study-referred to as MPT-250 and MPT-500, respectively. The main phenolic acids and flavonoids identified in MPT, with concentrations exceeding 10 mg/100 mL of tea, included catechin, rutin, salicylic acid, gallic acid, sinapic acid, chlorogenic acid, cinnamic acid, and ellagic acid. The total phenolic (TP) and total flavonoid (TF) contents in MPT were measured to be 5.53 and 7.73 mg/g, respectively. Additionally, MPT demonstrated a 57.2% scavenging capacity with 2,2-diphenyl-1-picrylhydrazyl radical. Notably, the administration of a higher dose (MPT-500) showed a significant reduction in body mass index (BMI) and a 51.24% reduction in the rate of increase in BW compared to the HFSD group. The findings indicated that all the treatment groups, that is, orlistat treatment (OT), MPT-250, and MPT-500 groups, experienced reduced levels of serum total cholesterol (TC), triglyceride (TG), and markers of lipoproteins in contrast to the HFSD group. Moreover, MPT helped restore the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH), thereby demonstrating its potential in combating oxidative stress. The MPT-500 group also displayed decreased liver and kidney weights and an improved atherogenic index when compared to the HFSD group. The results clearly indicate that a high dosage of MPT showed antiobesity activity which was comparable to the same effects produced by the conventional drug orlistat.
该研究旨在探究富含多酚的金盏花花瓣茶（MPT）对高脂高糖饮食（HFSD）大鼠模型氧化应激和肥胖的潜在作用。MPT通过传统煎煮方法制备，并采用反相高效液相色谱（RP-HPLC）对其多酚成分进行分析。本研究选择了两种特定剂量的MPT，即250和500毫克/千克体重（BW），分别称为MPT-250和MPT-500。MPT中鉴定出的主要酚酸和黄酮类化合物，其浓度超过10毫克/100毫升茶，包括儿茶素、芦丁、水杨酸、没食子酸、芥子酸、绿原酸、肉桂酸和鞣花酸。MPT中的总酚（TP）和总黄酮（TF）含量分别测定为5.53和7.73毫克/克。此外，MPT对2,2-二苯基-1-苦基肼自由基的清除能力为57.2%。值得注意的是，与HFSD组相比，给予较高剂量（MPT-500）可使体重指数（BMI）显著降低，体重增加率降低51.24%。研究结果表明，与HFSD组相比，所有治疗组，即奥利司他治疗（OT）组、MPT-250组和MPT-500组，血清总胆固醇（TC）、甘油三酯（TG）和脂蛋白标志物水平均降低。此外，MPT有助于恢复丙二醛（MDA）、超氧化物歧化酶（SOD）和还原型谷胱甘肽（GSH）的水平，从而证明其在对抗氧化应激方面的潜力。与HFSD组相比，MPT-500组的肝脏和肾脏重量也有所降低，动脉粥样硬化指数有所改善。结果清楚地表明，高剂量的MPT具有抗肥胖活性，与传统药物奥利司他产生的效果相当。
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