Lu Qin, Lu Jingjing, Li Che, Huang Ping, Jiang Fenfen, Zhao Xia, Zhang Jianqin, Huang Yi, Chu Zhenliang
Department of Cardiology The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Health Management Center The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Cardiovasc Ther. 2024 Aug 8;2024:8476971. doi: 10.1155/2024/8476971. eCollection 2024.
To observe the effects of cardiac rehabilitation guided by cardiopulmonary exercise testing (CPET) on cardiorespiratory reserve function, blood pressure, blood pressure variability, and lipid metabolism in patients with hypertension. A randomized trial enrolled 67 Grade 1 hypertensive patients on antihypertensive drugs, divided into conventional ( = 35) and CPET ( = 32) groups. Antihypertensive drugs were not adjusted in both groups during the study period. Blood pressure, cardiorespiratory indicators, lipid profile, and BMI were assessed pre/post 12 weeks. Postintervention, the CPET group exhibited significantly lower blood pressure levels and improved cardiac indicators compared to the conventional group ( < 0.05). CPET group showed greater improvements in cardiorespiratory endurance indicators ( < 0.05). The cardiorespiratory endurance indicators showed significantly greater increases in the CPET group compared to the conventional group ( < 0.05). Low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), and body mass index (BMI) were significantly lower in the CPET group ( < 0.05). In addition to drug treatment, cardiac rehabilitation guided by CPET can effectively improve blood pressure control, reduce blood pressure variability, improve cardiorespiratory function and lipid metabolism, and increase exercise endurance in patients with Grade 1 hypertension. Its efficacy is clear and safe, with clinical value for promotion.
观察心肺运动试验（CPET）指导的心脏康复对高血压患者心肺储备功能、血压、血压变异性和脂质代谢的影响。一项随机试验纳入了67例服用抗高血压药物的1级高血压患者，分为常规组（n = 35）和CPET组（n = 32）。研究期间两组均未调整抗高血压药物。在12周前后评估血压、心肺指标、血脂谱和BMI。干预后，与常规组相比，CPET组的血压水平显著降低，心脏指标得到改善（P < 0.05）。CPET组在心肺耐力指标方面有更大改善（P < 0.05）。与常规组相比，CPET组的心肺耐力指标显著升高（P < 0.05）。CPET组的低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）和体重指数（BMI）显著降低（P < 0.05）。除药物治疗外，CPET指导的心脏康复可有效改善1级高血压患者的血压控制，降低血压变异性，改善心肺功能和脂质代谢，并提高运动耐力。其疗效明确且安全，具有推广的临床价值。
