Xu Chenggang, Tang Le, Hu Lixin, Huang Yunzhe, Tang Jin, Wang Xiaohu, Wang Feng
Department of Cardiology XuanCheng City Central Hospital, Xuancheng, China.
Pharmacology College Anhui Xinhua University, Hefei, China.
Cardiovasc Ther. 2024 Jul 3;2024:4878103. doi: 10.1155/2024/4878103. eCollection 2024.
Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids, polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these, benzoylaconine, a pivotal active compound, demonstrates notable pharmacological properties including antitumor, anti-inflammatory, and cardiovascular protective effects. In recent years, benzoylaconine has garnered significant attention in basic research on heart diseases, emerging as a focal point of investigation. This paper presents a comprehensive review of the pharmacological effects of benzoylaconine, alongside an overview of advancements in metabolic characterization. The objective is to furnish valuable insights that can serve as a cornerstone for further exploration, utilization, and advancement of benzoylaconine in pharmacological research.
现代药理学研究已阐明附子的主要生物活性成分包括乌头碱（AC）生物碱、多糖和皂苷。其中，关键活性化合物苯甲酰乌头原碱具有显著的药理特性，包括抗肿瘤、抗炎和心血管保护作用。近年来，苯甲酰乌头原碱在心脏病基础研究中备受关注，成为研究焦点。本文全面综述了苯甲酰乌头原碱的药理作用，并概述了其代谢特征的研究进展。目的是提供有价值的见解，为苯甲酰乌头原碱在药理学研究中的进一步探索、利用和发展奠定基础。
