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New therapeutic target for alcohol-associated hepatitis (AH): AH-associated IL-8 neutrophils.

作者信息

Guan Yukun, Feng Dechun, Maccioni Luca, Wang Yang, Gao Bin

机构信息

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

eGastroenterology. 2024 Oct;2(4). doi: 10.1136/egastro-2024-100166. Epub 2024 Dec 21.

DOI:10.1136/egastro-2024-100166
PMID:39742140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11687388/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab44/11770423/5e03d2d11e02/egastro-2-4-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab44/11770423/5e03d2d11e02/egastro-2-4-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab44/11770423/5e03d2d11e02/egastro-2-4-g001.jpg

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IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis.白细胞介素-8阳性中性粒细胞在严重酒精性肝炎中引发不可阻挡的炎症。
J Clin Invest. 2024 Mar 19;134(9):e178616. doi: 10.1172/JCI178616.
2
THBS1 myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1.THBS1髓样细胞在SLD肝细胞癌中扩增，并通过TREM1导致免疫抑制和不良预后。
Cell Rep. 2024 Feb 27;43(2):113773. doi: 10.1016/j.celrep.2024.113773. Epub 2024 Feb 12.
3
Alcohol-associated liver disease.
Human liver immunology: from in vitro models to new insights.人类肝脏免疫学：从体外模型到新见解
Cell Mol Immunol. 2025 Jul 2. doi: 10.1038/s41423-025-01312-8.
4
Immune microenvironment in hepatocellular carcinoma: from pathogenesis to immunotherapy.肝细胞癌中的免疫微环境：从发病机制到免疫治疗
Cell Mol Immunol. 2025 Jun 11. doi: 10.1038/s41423-025-01308-4.
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Phytochemicals Targeting Inflammatory Pathways in Alcohol-Induced Liver Disease: A Mechanistic Review.针对酒精性肝病炎症通路的植物化学物质：一项机制综述
Pharmaceuticals (Basel). 2025 May 11;18(5):710. doi: 10.3390/ph18050710.
6
Opposite regulation of intestinal and intrahepatic CD8 T cells controls alcohol-associated liver disease progression.肠道和肝内CD8 T细胞的相反调节控制酒精性肝病的进展。
Gut. 2025 Jul 7;74(8):1308-1320. doi: 10.1136/gutjnl-2024-334412.
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J Gastroenterol. 2025 Mar 20. doi: 10.1007/s00535-025-02240-0.
酒精相关性肝病。
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J Hepatol. 2024 May;80(5):730-743. doi: 10.1016/j.jhep.2023.12.023. Epub 2024 Jan 8.
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Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.严重酒精性肝炎的独特组织病理学表型提示不同的机制导致肝损伤和衰竭。
J Clin Invest. 2022 Jul 15;132(14). doi: 10.1172/JCI157780.