Jiang Dongmei, Wang Jie, Wang Rui, Wu Yun
Department of General Medicine, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, China.
Department of Pharmacy, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, China.
Rev Cardiovasc Med. 2024 Nov 29;25(12):426. doi: 10.31083/j.rcm2512426. eCollection 2024 Dec.
Ventricular remodeling in right heart failure is a complex pathological process involving interactions between multiple mechanisms. Overactivation of the neuro-hormonal pathways, activation of the oxidative stress response, expression of cytokines, apoptosis of cardiomyocytes, and alterations of the extracellular matrix (ECM) are among the major mechanisms involved in the development of ventricular remodeling in right heart failure. These mechanisms are involved in ventricular remodeling, such as myocardial hypertrophy and fibrosis, leading to the deterioration of myocardial systolic and diastolic function. A deeper understanding of these mechanisms can help develop more effective therapeutic strategies in patients with right heart failure (RHF) to improve patient survival and quality of life. Despite the importance of ventricular remodeling in RHF, there are a limited number of studies in this field. This article explores in-depth historical and current information about the specific mechanisms in ventricular remodeling in RHF, providing a theoretical rationale for recognizing its importance in health and disease.
右心衰竭中的心室重构是一个复杂的病理过程，涉及多种机制之间的相互作用。神经激素途径的过度激活、氧化应激反应的激活、细胞因子的表达、心肌细胞凋亡以及细胞外基质（ECM）的改变是右心衰竭心室重构发生发展的主要机制。这些机制参与心室重构，如心肌肥厚和纤维化，导致心肌收缩和舒张功能恶化。深入了解这些机制有助于为右心衰竭（RHF）患者制定更有效的治疗策略，以提高患者生存率和生活质量。尽管心室重构在RHF中很重要，但该领域的研究数量有限。本文深入探讨了RHF心室重构具体机制的历史和当前信息，为认识其在健康和疾病中的重要性提供了理论依据。
