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颈动脉压力感受器刺激可改善肺动脉高压中的肺动脉重塑和右心室功能障碍。

Carotid Baroreceptor Stimulation Improves Pulmonary Arterial Remodeling and Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.

作者信息

Wang Jing, Chen Jie, Shu Ling, Zhang Ruoliu, Dai Mingyan, Fang Xuesheng, Hu Zhiling, Xiao Lingling, Xi Zhaoqing, Zhang Junxia, Bao Mingwei

机构信息

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

Cardiovascular Research Institute, Wuhan University, Wuhan, China.

出版信息

JACC Basic Transl Sci. 2024 Apr 22;9(4):475-492. doi: 10.1016/j.jacbts.2024.01.012. eCollection 2024 Apr.

DOI:10.1016/j.jacbts.2024.01.012
PMID:38680958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11055206/
Abstract

Autonomic nervous system imbalance is intricately associated with the severity and prognosis of pulmonary arterial hypertension (PAH). Carotid baroreceptor stimulation (CBS) is a nonpharmaceutical intervention for autonomic neuromodulation. The effects of CBS on monocrotaline-induced PAH were investigated in this study, and its underlying mechanisms were elucidated. The results indicated that CBS improved pulmonary hemodynamic status and alleviated right ventricular dysfunction, improving pulmonary arterial remodeling and right ventricular remodeling, thus enhancing the survival rate of monocrotaline-induced PAH rats. The beneficial effects of CBS treatment on PAH might be mediated through the inhibition of sympathetic overactivation and inflammatory immune signaling pathways.

摘要

自主神经系统失衡与肺动脉高压（PAH）的严重程度和预后密切相关。颈动脉窦压力感受器刺激（CBS）是一种用于自主神经调节的非药物干预措施。本研究探讨了CBS对野百合碱诱导的PAH的影响，并阐明了其潜在机制。结果表明，CBS改善了肺血流动力学状态，减轻了右心室功能障碍，改善了肺动脉重塑和右心室重塑，从而提高了野百合碱诱导的PAH大鼠的存活率。CBS治疗对PAH的有益作用可能是通过抑制交感神经过度激活和炎症免疫信号通路来介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/5311d05a97de/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/5311d05a97de/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/78af61874540/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/1678e6f0cb13/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/2e6ee96338e4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/e7da3492fc33/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/3fc67a47e687/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/6ec9831237c0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/824822169d39/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/5b337da05175/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcff/11055206/5311d05a97de/gr8.jpg

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Eur Respir J. 2023 Jan 6;61(1). doi: 10.1183/13993003.00879-2022. Print 2023 Jan.
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