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伊曲康唑成功治疗卡氏枝孢霉引起的着色芽生菌病:中国北方一例的临床病理学、药敏性及分子鉴定

Successful Treatment of Chromoblastomycosis caused by Cladophialophora carrionii with Itraconazole: Clinicopathology, Susceptibility, and Molecular Identification of a Case in Northern China.

作者信息

Li Yalong, Song Yinggai, Wang Aiping

机构信息

Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.

Research Center for Medical Mycology, Peking University, Beijing, China.

出版信息

Am J Trop Med Hyg. 2024 Dec 31;112(4):865-867. doi: 10.4269/ajtmh.24-0651. Print 2025 Apr 2.

DOI:10.4269/ajtmh.24-0651
PMID:39742523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11965731/
Abstract

Chromoblastomycosis (CBM), a prevalent subcutaneous mycosis in tropical and subtropical regions caused by dematiaceous fungi, often presents as refractory lesions. This case report details a 63-year-old woman from Tianjin, China, with CBM caused by Cladophialophora carrionii after plant trauma. Successful treatment with itraconazole was performed. After 3 months, the lesions improved significantly. The case highlights the importance of accurate diagnosis and tailored antifungal therapy, as well as the need for long-term follow-up because of the chronic nature of the disease.

摘要

着色芽生菌病(CBM)是一种由暗色真菌引起的在热带和亚热带地区流行的皮下真菌病,常表现为难治性病变。本病例报告详细介绍了一名来自中国天津的63岁女性,在植物外伤后感染了腐皮镰刀菌引起的CBM。采用伊曲康唑成功进行了治疗。3个月后,病变明显改善。该病例强调了准确诊断和针对性抗真菌治疗的重要性,以及由于疾病的慢性性质而需要长期随访的必要性。

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本文引用的文献

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Sporotrichosis: Using scanning electron microscopy to decipher the "blackish-red dot sign" observed under dermoscopy.孢子丝菌病:利用扫描电子显微镜解读皮肤镜下观察到的“黑红色点状征”
Skin Res Technol. 2024 Jun;30(6):e13775. doi: 10.1111/srt.13775.
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Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis.探讨着色芽生菌病的病因、微生物-宿主关系、免疫反应、诊断和治疗。
J Immunol Res. 2021 Nov 1;2021:9742832. doi: 10.1155/2021/9742832. eCollection 2021.
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Molecular identification of chromoblastomycosis clinical isolates in Guangdong.广东着色芽生菌病临床分离株的分子鉴定
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Chromoblastomycosis.着色芽生菌病
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Mycopathologia. 2013 Jun;175(5-6):477-88. doi: 10.1007/s11046-013-9648-x. Epub 2013 May 2.
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Mycoses. 2001;44(1-2):1-7. doi: 10.1046/j.1439-0507.2001.00613.x.