Xu Can, Mutwalli Hiba, Haslam Rowan, Keeler Johanna Louise, Treasure Janet, Himmerich Hubertus
Centre for Research in Eating and Weight Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Centre for Research in Eating and Weight Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
J Psychiatr Res. 2025 Jan;181:653-662. doi: 10.1016/j.jpsychires.2024.12.039. Epub 2024 Dec 25.
Studies suggest that there is a relationship between inflammatory diseases, inflammatory markers such as C-reactive protein (CRP) and psychiatric disorders. In eating disorders, cross-sectional studies have recently examined peripheral CRP levels in blood serum and plasma, which allow a comprehensive meta-analysis. This systematic review and meta-analysis examined studies from three databases, measuring CRP levels in people with eating disorders, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total n = 14 publications were included into the systematic review. Of these, n = 13 cross-sectional papers with N = 700 participants were meta-analysed, n = 11 in anorexia nervosa (AN) and n = 2 in binge eating disorder (BED). One study of the total n = 14 was narratively summarised because it was not suitable for inclusion into the meta-analysis. In the cross-sectional analyses, CRP levels were significantly lower in people with AN compared to health controls (HCs), but CRP level were higher in people with BED compared to HCs. Patients with AN appear to have lower CRP levels compared to healthy controls. This could be a result of malnutrition or specific nutritional deficiencies. Due to the reduced CRP levels in AN, patients might be at risk for bacterial infections or developing autoimmune diseases, and clinicians might fail to notice an inflammatory process or an infection. In contrast, patients with BED were found to have higher CRP level than healthy controls which might be a consequence of an inflammatory response triggered by overeating, disordered eating patterns and the consumption of low-quality food during binges.
研究表明，炎症性疾病、C反应蛋白（CRP）等炎症标志物与精神障碍之间存在关联。在饮食失调方面，横断面研究最近检测了血清和血浆中的外周CRP水平，这使得全面的荟萃分析成为可能。本系统评价和荟萃分析按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，检索了三个数据库中测量饮食失调患者CRP水平的研究。系统评价共纳入了n = 14篇出版物。其中，对n = 13篇横断面论文进行了荟萃分析，这些论文共有N = 700名参与者，其中神经性厌食症（AN）患者11篇，暴饮暴食症（BED）患者2篇。由于一篇研究不适合纳入荟萃分析，因此对总共n = 14篇研究中的一篇进行了叙述性总结。在横断面分析中，与健康对照（HC）相比，AN患者的CRP水平显著较低，但与HC相比，BED患者的CRP水平较高。与健康对照相比，AN患者的CRP水平似乎较低。这可能是营养不良或特定营养缺乏的结果。由于AN患者的CRP水平降低，他们可能有细菌感染或患自身免疫性疾病的风险，临床医生可能无法注意到炎症过程或感染。相比之下，发现BED患者的CRP水平高于健康对照，这可能是暴饮暴食、饮食模式紊乱以及在暴饮暴食期间食用低质量食物引发的炎症反应的结果。
