Gu Chen-Lin, Zhang Lu, Zhu Yan, Bao Ting-Yu, Zhu Yu-Ting, Chen Yu-Tong, Pang Han-Qing
Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou 225009, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, China.
The Radiology Department of Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, China.
Neuroscience. 2025 Feb 6;566:190-197. doi: 10.1016/j.neuroscience.2024.12.049. Epub 2024 Dec 30.
Vascular obstruction often causes inadequate oxygen and nutrient supply to the brain. This deficiency results in cerebral ischemic injury, which significantly impairs neurological function. This review aimed to explore the neuroprotective and regenerative effects of nerve growth factor (NGF) in cerebral ischemic injury. NGF, a crucial neurotrophic factor, could inhibit neuronal apoptosis, reduce inflammatory responses, and promote axon regeneration and angiogenesis through its interaction with TrkA, a high-affinity receptor. These functions were closely related to the activation of Phosphatidylinositol 3-kinase/Protein kinase B (PI3K/AKT) and Mitogen-Activated Protein Kinase (MAPK) pathways. Moreover, the mechanisms of NGF in the acute and recovery phases, along with the strategies to enhance its therapeutic effects using delivery systems (such as intranasal administration, nanovesicles, and gene therapy) were also summarized. Although NGF shows great potential for clinical application, its delivery efficiency and long-term safety still need more research and improvements. Future research should focus on exploring the specific action mechanism of NGF, optimizing the delivery strategy, and evaluating its long-term efficacy and safety to facilitate its clinical transformation in cerebral ischemic stroke.
血管阻塞常常导致大脑的氧气和营养供应不足。这种不足会导致脑缺血损伤，严重损害神经功能。本综述旨在探讨神经生长因子（NGF）在脑缺血损伤中的神经保护和再生作用。NGF是一种关键的神经营养因子，它可以通过与高亲和力受体TrkA相互作用，抑制神经元凋亡，减少炎症反应，并促进轴突再生和血管生成。这些功能与磷脂酰肌醇3激酶/蛋白激酶B（PI3K/AKT）和丝裂原活化蛋白激酶（MAPK）信号通路的激活密切相关。此外，还总结了NGF在急性期和恢复期的作用机制，以及利用递送系统（如鼻内给药、纳米囊泡和基因治疗）增强其治疗效果的策略。尽管NGF在临床应用中显示出巨大潜力，但其递送效率和长期安全性仍需更多研究和改进。未来的研究应集中在探索NGF的具体作用机制、优化递送策略以及评估其长期疗效和安全性，以促进其在脑缺血性卒中中的临床转化。
