Fan Siyu, Chen Yingcong, Yao Weijing, Yi Cong
Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
J Zhejiang Univ Sci B. 2024 Apr 3;25(12):1066-1070. doi: 10.1631/jzus.B2300884.
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient deprivation-induced autophagy, the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy. Using the model organisms and mammalian cells, we found that cellular reactive oxygen species (ROS), DNA damage sensor Mec1, and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation. This review aims to provide a concise overview of these research findings.
自噬在响应各种刺激以维持细胞内稳态方面发挥着关键作用。与营养剥夺诱导的自噬研究相比，我们对能量剥夺引发的自噬的分子机制及其生理/病理意义的了解仍然有限。我们实验室的主要重点是阐明细胞如何感知能量剥夺并启动自噬。利用模式生物和哺乳动物细胞，我们发现细胞活性氧（ROS）、DNA损伤传感器Mec1和线粒体有氧呼吸在能量剥夺诱导的自噬中起着至关重要的作用。本综述旨在简要概述这些研究结果。
