Jagua-Gualdrón Andrés, García-Reyes Nicolai Andrés, Fernández-Bernal Roger Edwin
National University of Colombia, Bogota, Colombia.
International Institute for Complementary and Alternative Medicine-IIMAN, Bogota, Colombia.
J Complement Integr Med. 2025 Jan 1;22(2):228-236. doi: 10.1515/jcim-2024-0367. eCollection 2025 Jun 1.
Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces a significant impact on health and leads to complications that are difficult to manage.
This review summarizes and analyzes recent advances in the understanding of the mechanisms of diabetes mellitus and how apitherapy affects them. Also present the available clinical evidence on its application.
Apitherapy (complementary-integral use of beehive products) is a potentially useful therapeutic system with a significant level of evidence. This review shows and analyzes the preclinical and clinical evidence on the use of apitherapy in diabetes mellitus.
Apitherapy shows significant effects on epigenetics, chronic inflammation, oxidative stress, metabolic control, dysbiosis, premature cell death and tissue remodeling. Clinical evidence shows an impact on these mechanisms. Apitherapy is a very useful complementary medicine in the treatment of diabetes mellitus.
糖尿病在病因和病理生理过程方面是一种复杂的疾病，它对健康产生重大影响，并导致难以控制的并发症。
本综述总结并分析了对糖尿病发病机制的最新认识进展以及蜂疗如何对其产生影响。还介绍了其应用的现有临床证据。
蜂疗（蜂巢产品的综合互补应用）是一个有大量证据支持的潜在有用治疗体系。本综述展示并分析了蜂疗用于糖尿病治疗的临床前和临床证据。
蜂疗在表观遗传学、慢性炎症、氧化应激、代谢控制、菌群失调、细胞过早死亡和组织重塑方面显示出显著效果。临床证据表明其对这些机制有影响。蜂疗是治疗糖尿病非常有用的补充医学手段。
