Sadeghi Fatemeh, Salehi Saedeh, Kohanmoo Ali, Akhlaghi Masoumeh
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Prev Med. 2019 Jan 15;10:3. doi: 10.4103/ijpvm.IJPVM_109_18. eCollection 2019.
Due to high content of fructose, honey has been introduced as a suitable natural sweetener for patients with type 2 diabetes. We investigated the effect of honey consumption on glycemic control and anthropometric measures of patients with type 2 diabetes.
This randomized controlled crossover clinical trial was conducted on 53 patients with type 2 diabetes. The participants were randomly divided into groups of control (weight maintenance diet) or treatment (weight maintenance diet +50 g/day honey) for 8 weeks. After a 4-week washout, the second phase began, in which the role of the groups was interchanged. Blood glycated hemoglobin (HbA1c), glucose, insulin, and anthropometric characteristics were measured. Statistical analysis was performed with SPSS. Repeated measures of ANOVA were used to test differences within- and between the two conditions.
Forty-two patients completed the study. HbA1c significantly decreased in control (-0.22%, = 0.03) and nonsignificantly increased in honey condition (+0.17%, = 0.22). There was a significant difference between the two conditions ( = 0.02). Fasting glucose did not significantly change in either honey or control condition but insulin concentrations (-0.85 μU/ml, = 0.01) and insulin secretion (-10.7%, = 0.01) decreased significantly in the control condition. There was no significant difference in any of these parameters between the two conditions. Waist circumference decreased by honey treatment with a significant difference between the two conditions ( = 0.02).
Eight weeks consumption of 50 g/day honey increased HbA1c and decreased waist circumference of patients with type 2 diabetes.
由于果糖含量高，蜂蜜已被推荐为2型糖尿病患者适用的天然甜味剂。我们研究了食用蜂蜜对2型糖尿病患者血糖控制和人体测量指标的影响。
本随机对照交叉临床试验对53例2型糖尿病患者进行。参与者被随机分为对照组（维持体重饮食）或治疗组（维持体重饮食+每日50克蜂蜜），为期8周。经过4周的洗脱期后，第二阶段开始，两组角色互换。测量糖化血红蛋白（HbA1c）、血糖、胰岛素和人体测量特征。使用SPSS进行统计分析。采用重复测量方差分析来检验两种情况内和两种情况间的差异。
42例患者完成了研究。对照组的HbA1c显著降低（-0.22%，P = 0.03），而蜂蜜组无显著升高（+0.17%，P = 0.22）。两种情况之间存在显著差异（P = 0.02）。蜂蜜组和对照组的空腹血糖均无显著变化，但对照组的胰岛素浓度（-0.85 μU/ml，P = 0.01）和胰岛素分泌（-10.7%，P = 0.01）显著降低。两种情况在这些参数上均无显著差异。蜂蜜治疗使腰围减小，两种情况之间存在显著差异（P = 0.02）。
每天食用50克蜂蜜8周会使2型糖尿病患者的HbA1c升高，腰围减小。
