Zhang Ziwei, Xiong Rui, Hu Qiyan, Zhang Qiang, Wang Shaozhen, Chen Yunyan
School of Pharmacy, Wannan Medical College, Wuhu, China.
Institute of Synthesis and Application of Medical Materials, Wannan Medical College, Wuhu, China.
J Drug Target. 2025 Jun;33(5):704-716. doi: 10.1080/1061186X.2024.2448708. Epub 2025 Jan 3.
In recent years, the use of traditional Chinese medicine (TCM) in the treatment of cancer has received widespread attention. Treatment of tumours using TCM can effectively reduce the side effects of anti-tumour drugs, meanwhile to improve the treatment efficacy of patients. However, most of the active ingredients in TCM, such as saponins, alkaloids, flavonoids, volatile oils, etc., have defects such as low bioavailability and poor solubility in clinical application, which seriously restrict the application of TCM. Meanwhile, the encapsulation of TCM into lipid nano-delivery systems for cancer therapy has received much attention. Lipid nano-delivery systems are obtained by using phospholipids as the base material and adding other auxiliary materials under a certain preparation process, including, for example, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), microemulsions, and self-microemulsion drug delivery systems (SMEDDS), can resolve the application problems of TCM by improving the efficacy of active ingredients of TCM and reducing the toxicity of anti-tumour drugs. This paper focuses on the categories, development status, and research progress of lipid nano delivery system of TCM, aiming to provide a certain theoretical basis for further in-depth research and rational application of these systems.
近年来，中药在癌症治疗中的应用受到广泛关注。使用中药治疗肿瘤可有效减轻抗肿瘤药物的副作用，同时提高患者的治疗效果。然而，中药中的大多数活性成分，如皂苷、生物碱、黄酮类、挥发油等，在临床应用中存在生物利用度低、溶解度差等缺陷，严重限制了中药的应用。同时，将中药包裹于脂质纳米递送系统用于癌症治疗备受关注。脂质纳米递送系统是以磷脂为基础材料，在一定制备工艺下添加其他辅料而得到的，包括脂质体、固体脂质纳米粒（SLNs）、纳米结构脂质载体（NLCs）、微乳、自微乳化药物递送系统（SMEDDS）等，可通过提高中药活性成分的疗效和降低抗肿瘤药物的毒性来解决中药的应用问题。本文重点阐述中药脂质纳米递送系统的类别、发展现状及研究进展，旨在为这些系统的进一步深入研究和合理应用提供一定的理论依据。
