中药生物活性化合物的纳米递药系统：在前列腺癌治疗中的应用。
Nanodelivery system of traditional Chinese medicine bioactive compounds: Application in the treatment of prostate cancer.
机构信息
The First Hospital of Hunan University of Chinese Medicine, 95, Changsha 410007, Hunan, China.
Hunan University of Chinese Medicine, 300, Changsha 410208, Hunan, China.
出版信息
Phytomedicine. 2024 Dec;135:155554. doi: 10.1016/j.phymed.2024.155554. Epub 2024 Mar 29.
BACKGROUND
The long history of clinical experience in China have confirmed the effectiveness of traditional Chinese medicine (TCM) in treating prostate cancer (PCa). Until now, several bioactive compounds with anti-PCa potential, such as curcumin, gallic acid, and quercetin, have been extracted from TCM. Recent studies have shown that encapsulating these TCM bioactive compounds into nano-delivery system enhanced their bioavailability and improved their ability to target PCa tumors.
PURPOSE
This review aims to summarize the anti-PCa effects and molecular mechanisms of TCM bioactive compounds and discuss the clinical application prospects and future research trends of nano-delivery system based on these compounds.
METHODS
Literatures focusing on the treatment of PCa using traditional Chinese medicine compounds via nano-drug delivery system were searched from Electronic databases, including PubMed, Web of Science, and Scopus until December 2023.
RESULTS
Polyphenols, alkaloids, terpenes, and quinones exhibit anti-PCa effects through various pathways. Notably, compounds like curcumin, gallic acid, quercetin, and tanshinone have been extensively studied in nano-delivery systems for anti-PCa purpose. Nano-delivery systems enhance the biological activity of free compounds and reduce toxic side effects, as well. Commonly used nanomaterials for delivering TCM compounds include polymer nanomaterials, liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and niosomes.
CONCLUSION
Research on nano-delivery systems for TCM bioactive compounds holds promising prospects for anti-PCa therapy. However, extensive clinical trials are necessary to evaluate the effectiveness and safety of these nanodrugs.
背景
中国悠久的临床经验证实了中医药（TCM）在治疗前列腺癌（PCa）方面的有效性。迄今为止，已经从 TCM 中提取出了几种具有抗 PCa 潜力的生物活性化合物，如姜黄素、没食子酸和槲皮素。最近的研究表明，将这些 TCM 生物活性化合物封装到纳米递药系统中可以提高它们的生物利用度，并增强它们靶向 PCa 肿瘤的能力。
目的
本综述旨在总结 TCM 生物活性化合物的抗 PCa 作用和分子机制，并讨论基于这些化合物的纳米递药系统的临床应用前景和未来研究趋势。
方法
从电子数据库（包括 PubMed、Web of Science 和 Scopus）中检索了关于使用传统中药化合物通过纳米药物递送系统治疗 PCa 的文献，检索时间截至 2023 年 12 月。
结果
多酚、生物碱、萜类化合物和醌类化合物通过多种途径发挥抗 PCa 作用。值得注意的是，姜黄素、没食子酸、槲皮素和丹参酮等化合物已在抗 PCa 的纳米递药系统中得到了广泛研究。纳米递药系统增强了游离化合物的生物活性，同时降低了毒性副作用。用于递送 TCM 化合物的常见纳米材料包括聚合物纳米材料、脂质体、固体脂质纳米粒、纳米结构脂质载体和非诺司他。
结论
研究 TCM 生物活性化合物的纳米递药系统为抗 PCa 治疗提供了广阔的前景。然而，需要进行广泛的临床试验来评估这些纳米药物的有效性和安全性。
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