Wu Jin, Meng Tao, Zhang Xiaoqian, Tang Songtao, Liu Lei, Xue Jing, Liu Xiaohui, Wang Junjun, Wen Jiyue, Hu Danyou, Zhang Guiyang
Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230031, China.
Adv Healthc Mater. 2025 Mar;14(6):e2404076. doi: 10.1002/adhm.202404076. Epub 2025 Jan 2.
Effective glycemic control is paramount for optimal wound healing in diabetic patients. Traditional antibacterial and anti-inflammatory treatments, while important, often fall short in addressing the hyperglycemic conditions of diabetic wounds. Therefore, the development of novel therapeutic strategies for accelerating diabetic wound healing has garnered escalating attention. Covalent organic frameworks (COFs) are an emerging class of crystalline porous polymers constructed through strong covalent bonds. Their exceptional structural tunability renders them as an ideal platform for advanced therapeutic applications. Herein, two redox-responsive Zn(II)-coordinated porphyrin COF hydrogels are constructed, which demonstrate rapid blood glucose reduction in localized tissues, along with improved angiogenesis, reactive oxygen species (ROS) scavenging, and photothermal antimicrobial capacities within the hyperglycemic blood environment of diabetic patients, thereby effectively controlling infections and concurrently promoting wound healing. Specifically, COFs with built-in dual active sites, i.e., disulfide or diselenide moieties, can be cleaved by ROS, releasing Zn(II) ions that possess antibacterial and tissue-repairing properties. Furthermore, the Zn(II)-porphyrin COF exhibits glucose oxidase (GOX)-like activity, catalyzing the conversion of glucose into non-glucose metabolites. This synergistic combination of glucose-responsive Zn(II) release and GOX-like activities effectively restores tissue redox balance and improves the wound microenvironment, offering a promising strategy for the diagnosis and treatment of diabetic wounds.
有效的血糖控制对于糖尿病患者实现最佳伤口愈合至关重要。传统的抗菌和抗炎治疗虽然重要，但在解决糖尿病伤口的高血糖状况方面往往不足。因此，开发加速糖尿病伤口愈合的新型治疗策略已引起越来越多的关注。共价有机框架（COF）是一类新兴的通过强共价键构建的结晶多孔聚合物。它们卓越的结构可调性使其成为先进治疗应用的理想平台。在此，构建了两种氧化还原响应性锌（II）配位卟啉COF水凝胶，它们在局部组织中显示出快速的血糖降低，同时在糖尿病患者的高血糖血液环境中具有改善的血管生成、活性氧（ROS）清除和光热抗菌能力，从而有效控制感染并同时促进伤口愈合。具体而言，具有内置双活性位点（即二硫键或二硒键部分）的COF可被ROS裂解，释放出具有抗菌和组织修复特性的锌（II）离子。此外，锌（II）-卟啉COF表现出类似葡萄糖氧化酶（GOX）的活性，催化葡萄糖转化为非葡萄糖代谢物。这种葡萄糖响应性锌（II）释放和类似GOX活性的协同组合有效地恢复了组织氧化还原平衡并改善了伤口微环境，为糖尿病伤口的诊断和治疗提供了一种有前景的策略。
