去势和睾酮治疗对雄性大鼠己巴比妥敏感性的影响。
Effects of castration and testosterone treatment on the hexobarbital sensitivity in male rats.
作者信息
Bolander H G, Kourtopoulos H
出版信息
Life Sci. 1985 Mar 11;36(10):907-12. doi: 10.1016/0024-3205(85)90385-6.
PMID:3974400
Abstract
Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats.
摘要
通过脑电图阈值法测量发现，阉割会增加中枢神经系统（CNS）对己巴比妥的敏感性。以1至5毫克/千克/天的剂量进行睾酮治疗，可降低中枢神经系统的敏感性，并使阉割大鼠的阈值恢复到正常年轻成年雄性大鼠的水平。
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