Liu Chenan, Liu Tong, Wei Yaping, Shi Jinyu, Deng Li, Song Mengmeng, Shi Hanping
Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Front Pharmacol. 2024 Dec 18;15:1507125. doi: 10.3389/fphar.2024.1507125. eCollection 2024.
Amino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways. This study sought to explore the associations between serum levels of these amino acids and cancer risk within Chinese adults.
A nested case-control study was conducted within the China H-Type Hypertension Registry Study cohort, comprising 1,391 cancer cases and 1,391 matched controls. Serum concentrations of taurine, SAM, and cysteine were quantified, and their associations with cancer risk were evaluated using conditional logistic regression and Bayesian Kernel Machine Regression (BKMR) models.
A total of 1,391 pairs of participants were included in this study. Their average age was 69.3 years ± 7.77 years, and 56% were male. Higher serum taurine levels were associated with a reduced risk of overall cancer. In contrast, elevated serum SAM levels were linked to an increased risk of digestive cancers. The BKMR model identified complex interactions among these amino acids and showed a significant overall negative association between the combined effect of taurine, SAM, and cysteine and cancer risk.
Serum taurine levels may offer protective benefits against cancer, particularly for digestive cancers, while its metabolites do not have such significant benefits. The intricate interactions among taurine, SAM, and cysteine underscore the need for a comprehensive approach to understanding their roles in the metabolic processes that drive tumorigenesis.
https://www.chictr.org.cn/showproj.html?proj=28262, identifier ChiCTR1800017274.
已知氨基酸在癌症代谢和进展中发挥关键作用。其中，牛磺酸、S-腺苷甲硫氨酸（SAM）和半胱氨酸因其相互关联的代谢途径而受到特别关注。本研究旨在探讨中国成年人血清中这些氨基酸水平与癌症风险之间的关联。
在中国H型高血压注册研究队列中进行了一项巢式病例对照研究，包括1391例癌症病例和1391例匹配对照。对血清中牛磺酸、SAM和半胱氨酸的浓度进行定量，并使用条件逻辑回归和贝叶斯核机器回归（BKMR）模型评估它们与癌症风险的关联。
本研究共纳入1391对参与者。他们的平均年龄为69.3岁±7.77岁，56%为男性。较高的血清牛磺酸水平与总体癌症风险降低相关。相反，血清SAM水平升高与消化系统癌症风险增加有关。BKMR模型确定了这些氨基酸之间的复杂相互作用，并显示牛磺酸、SAM和半胱氨酸的联合作用与癌症风险之间存在显著的总体负相关。
血清牛磺酸水平可能对癌症具有保护作用，尤其是对消化系统癌症，而其代谢产物则没有如此显著的益处。牛磺酸、SAM和半胱氨酸之间的复杂相互作用强调了需要采用综合方法来理解它们在驱动肿瘤发生的代谢过程中的作用。
https://www.chictr.org.cn/showproj.html?proj=28262，标识符ChiCTR1800017274。
