Song Yuqing, Chen Yanling, Wen Liting, He Benyi, Ding Yulin, Liu Mei, Tang Fangmei, Wang Li, Wu Jianmei, Deng Xue, Xing Lu, Zhao Wen
Department of Gynecological Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
Front Public Health. 2024 Dec 18;12:1478376. doi: 10.3389/fpubh.2024.1478376. eCollection 2024.
Rheumatoid arthritis (RA) is a common rheumatic disease that most commonly affects joints and negatively impacts individuals' health-related quality of life (HRQoL). Although some studies have explored HRQoL of RA patients, existing studies treated RA patients as a homogeneous group based on their overall HRQoL and ignore the heterogeneity of patients' HRQoL patterns. This study aimed to identify subgroups of RA patients based on their HRQoL and variables associated with group membership.
This was a multi-center cross-sectional study conducted at 3 tertiary hospitals. All participants completed standardized questionnaires including demographic variables, HRQoL, physical function, disease activity and self-efficacy. Latent profile analysis was used to identify the optimal number of subgroups (profiles) and multinomial logistic regression analysis was used to explore variables associated with profile membership.
The analysis revealed 3 profiles of RA patients: poor HRQoL ( = 92, 60.9%), moderate HRQoL but poor role function ( = 45, 29.8%), good HRQoL ( = 14, 9.3%). Regression analysis revealed that patients with worse physical function were more likely to belong to "poor HRQoL" and "moderate HRQoL but poor role function" profile. Additionally, patients with junior high school or below educational level were less likely to belong to "moderate HRQoL but poor role function" profile.
This study identified 3 profiles of HRQoL within RA patients and found that physical function and educational level was associated with HRQoL profiles. The finding can provide the basis for developing tailored interventions to specific subgroups of RA patients.
类风湿性关节炎（RA）是一种常见的风湿性疾病，最常影响关节，并对个体的健康相关生活质量（HRQoL）产生负面影响。尽管一些研究探讨了RA患者的HRQoL，但现有研究根据RA患者的总体HRQoL将其视为一个同质群体，而忽略了患者HRQoL模式的异质性。本研究旨在根据RA患者的HRQoL及其组成员相关变量确定亚组。
这是一项在3家三级医院进行的多中心横断面研究。所有参与者均完成了标准化问卷，包括人口统计学变量、HRQoL、身体功能、疾病活动度和自我效能感。采用潜在剖面分析确定亚组（剖面）的最佳数量，并采用多项逻辑回归分析探讨与剖面组成员相关的变量。
分析揭示了RA患者的3种剖面：HRQoL差（n = 92，60.9%）、HRQoL中等但角色功能差（n = 45，29.8%）、HRQoL良好（n = 14，9.3%）。回归分析显示，身体功能较差的患者更有可能属于“HRQoL差”和“HRQoL中等但角色功能差”剖面。此外，初中及以下教育水平的患者属于“HRQoL中等但角色功能差”剖面的可能性较小。
本研究确定了RA患者中的3种HRQoL剖面，并发现身体功能和教育水平与HRQoL剖面相关。这一发现可为针对特定RA患者亚组制定个性化干预措施提供依据。
