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在SARS-CoV-2疫情期间确保用于生产洗手液的本地采购酒精的安全性:全面杂质分析

Ensuring the Safety of Locally Sourced Alcohols for Hand Sanitizer Production During the SARS-CoV-2 Crisis: A Comprehensive Impurity Analysis.

作者信息

Jurado Camille, Ramjaun Zoubeir, El Balkhi Souleiman, Saint-Marcoux Franck, Alonso Mathieu, Salabert Anne Sophie, Durand Fanny, Caturla Laetitia, Metsu David, Gardes Emilie, Quelven-Bertin Isabelle, Cestac Philippe

机构信息

Toulouse University Hospital, Toulouse, France.

University Hospital Centre of Limoges, Limoges, France.

出版信息

Hosp Pharm. 2024 Dec 30:00185787241309254. doi: 10.1177/00185787241309254.

Abstract

Amid the early 2020 SARS-CoV-2 crisis, severe hand sanitizer shortages led to OMS local production recommendations, inviting a diverse array of alcohol producers to contribute. However, not all followed mandatory controls for API-grade alcohol. We conducted a study to ensure the safety of the received alcohols, focusing on methanol and acetaldehyde levels. All samples were well below Ph. Eur guidelines, affirming their safety for use. Furthermore, no additional impurities were detected, reinforcing the quality and safety of the assessed hand sanitizers. Our findings, amidst the scarcity of the SARS-CoV-2 era, highlight the importance of rigorous safety assessments during local hand sanitizer production.

摘要

在2020年初新型冠状病毒危机期间,严重的洗手液短缺促使世界卫生组织提出本地生产建议,吸引了众多酒精生产商参与。然而,并非所有生产商都遵循原料药级酒精的强制管控要求。我们开展了一项研究以确保所接收酒精的安全性,重点关注甲醇和乙醛含量。所有样品均远低于欧洲药典指南标准,证实了其使用安全性。此外,未检测到其他杂质,进一步证明了所评估洗手液的质量和安全性。我们在新型冠状病毒时代物资匮乏的背景下所取得的研究结果,凸显了本地生产洗手液过程中进行严格安全评估的重要性。

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