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Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance.

作者信息

Guerra Leal Bárbara, Carvalho Cláudia, Santos Cristina, Samões Raquel, Martins-Ferreira Ricardo, Teixeira Catarina, Rodrigues Diana, Freitas Joel, Lemos Carolina, Chorão Rui, Ramalheira João, Lopes João, Martins da Silva António, Pinho E Costa Paulo, Chaves João

机构信息

UMIB-Unit for Multidisciplinary Research in Biomedicine, ICBAS- Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Porto, Portugal.

ITR-Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal.

出版信息

Front Mol Neurosci. 2024 Dec 18;17:1512860. doi: 10.3389/fnmol.2024.1512860. eCollection 2024.

DOI:10.3389/fnmol.2024.1512860
PMID:39744540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688299/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/1a6cd1abbc22/fnmol-17-1512860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/57c64400c2a8/fnmol-17-1512860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/aed5795a6d3c/fnmol-17-1512860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/eb098b3cd1a4/fnmol-17-1512860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/1a6cd1abbc22/fnmol-17-1512860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/57c64400c2a8/fnmol-17-1512860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/aed5795a6d3c/fnmol-17-1512860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/eb098b3cd1a4/fnmol-17-1512860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c562/11688299/1a6cd1abbc22/fnmol-17-1512860-g004.jpg

相似文献

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Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance.内侧颞叶癫痫中循环miR-134：对海马硬化发展和耐药性的影响
Front Mol Neurosci. 2024 Dec 18;17:1512860. doi: 10.3389/fnmol.2024.1512860. eCollection 2024.
2
MicroRNAs miR-629-3p, miR-1202 and miR-1225-5p as potential diagnostic and surgery outcome biomarkers for mesial temporal lobe epilepsy with hippocampal sclerosis.微小 RNA（miRNA）miR-629-3p、miR-1202 和 miR-1225-5p 作为内侧颞叶癫痫伴海马硬化的潜在诊断和手术预后生物标志物。
Neurochirurgie. 2022 Dec;68(6):583-588. doi: 10.1016/j.neuchi.2022.06.002. Epub 2022 Jun 11.
3
MicroRNA hsa-miR-134 is a circulating biomarker for mesial temporal lobe epilepsy.微小RNA hsa-miR-134是内侧颞叶癫痫的一种循环生物标志物。
PLoS One. 2017 Apr 6;12(4):e0173060. doi: 10.1371/journal.pone.0173060. eCollection 2017.
4
Expression of circulating microRNAs as predictors of diagnosis and surgical outcome in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.循环微小RNA的表达作为内侧颞叶癫痫伴海马硬化患者诊断及手术结果预测指标的研究
Epilepsy Res. 2020 Oct;166:106373. doi: 10.1016/j.eplepsyres.2020.106373. Epub 2020 May 22.
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Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22.内侧颞叶癫痫（MTLE）的药物难治性与人类海马体和颞叶新皮质中P2X7受体的过表达相关，并且可能由循环中低水平的miR-22预测。
Front Cell Neurosci. 2022 Jul 7;16:910662. doi: 10.3389/fncel.2022.910662. eCollection 2022.
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Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis.伴有海马硬化的内侧颞叶癫痫患者血浆外泌体中微小RNA谱的改变
Oncotarget. 2017 Jan 17;8(3):4136-4146. doi: 10.18632/oncotarget.13744.
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Expression of MicroRNAs miR-145, miR-181c, miR-199a and miR-1183 in the Blood and Hippocampus of Patients with Mesial Temporal Lobe Epilepsy.微 RNA miR-145、miR-181c、miR-199a 和 miR-1183 在伴海马硬化颞叶内侧癫痫患者血液和海马中的表达。
J Mol Neurosci. 2019 Dec;69(4):580-587. doi: 10.1007/s12031-019-01386-w. Epub 2019 Jul 31.
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MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus.微小RNA与海马硬化所致内侧颞叶癫痫：人类海马的全微小RNA组分析
Epilepsia. 2017 Oct;58(10):1782-1793. doi: 10.1111/epi.13870. Epub 2017 Aug 16.
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Amygdala enlargement occurs in patients with mesial temporal lobe epilepsy and hippocampal sclerosis with early epilepsy onset.杏仁核增大发生于癫痫早期发病的内侧颞叶癫痫和海马硬化患者中。
Epilepsy Behav. 2013 Nov;29(2):390-4. doi: 10.1016/j.yebeh.2013.08.022. Epub 2013 Sep 24.
10
Differential regulation of excitatory synaptic transmission in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).细胞周期蛋白依赖性激酶 5（Cdk5）在伴有海马硬化的内侧颞叶癫痫（MTLE-HS）中对海马和前颞叶兴奋性突触传递的差异调节。
Neurosci Lett. 2021 Sep 14;761:136096. doi: 10.1016/j.neulet.2021.136096. Epub 2021 Jul 1.

本文引用的文献

1
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy.实验性颞叶癫痫中循环微小RNA生物标志物的脑细胞特异性起源
Front Mol Neurosci. 2023 Sep 22;16:1230942. doi: 10.3389/fnmol.2023.1230942. eCollection 2023.
2
Drug resistance in epilepsy.癫痫的耐药性。
Lancet Neurol. 2023 Aug;22(8):723-734. doi: 10.1016/S1474-4422(23)00151-5. Epub 2023 Jun 20.
3
MicroRNA inhibition using antimiRs in acute human brain tissue sections.使用抗 miRNA 在急性人脑组织切片中抑制 microRNA。
Epilepsia. 2022 Aug;63(8):e92-e99. doi: 10.1111/epi.17317. Epub 2022 Jun 20.
4
AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome.针对微小RNA-134的抗微小RNA可减少天使综合征小鼠模型中的癫痫发作。
Mol Ther Nucleic Acids. 2022 Apr 20;28:514-529. doi: 10.1016/j.omtn.2022.04.009. eCollection 2022 Jun 14.
5
The global cost of epilepsy: A systematic review and extrapolation.全球癫痫的经济负担：系统回顾与外推。
Epilepsia. 2022 Apr;63(4):892-903. doi: 10.1111/epi.17165. Epub 2022 Feb 23.
6
Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long-term outcome.癫痫患者的共病：发生率、机制及对长期预后的影响
Epilepsia. 2021 Oct;62(10):2395-2404. doi: 10.1111/epi.17022. Epub 2021 Jul 26.
7
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice.抗义寡核苷酸介导的 microRNA-134 抑制减少了幼鼠海人酸诱导的癫痫发作。
Sci Rep. 2021 Jan 11;11(1):340. doi: 10.1038/s41598-020-79350-7.
8
MicroRNAs as regulators of brain function and targets for treatment of epilepsy.微小 RNA 作为脑功能的调节剂和癫痫治疗的靶点。
Nat Rev Neurol. 2020 Sep;16(9):506-519. doi: 10.1038/s41582-020-0369-8. Epub 2020 Jun 16.
9
Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures.循环 miR-146a 和 miR-134 预测局灶性意识障碍性癫痫患者的耐药性癫痫。
Epilepsia. 2020 May;61(5):959-970. doi: 10.1111/epi.16502. Epub 2020 Apr 21.
10
Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel.循环 microRNAs 作为遗传性全面性癫痫的潜在生物标志物：一个三 microRNA 组合。
Eur J Neurol. 2020 Apr;27(4):660-666. doi: 10.1111/ene.14129. Epub 2019 Dec 15.