Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant : A Case Report.

Ventriculoperitoneal shunts (VPSs) have been proven to be life-saving procedures, but their complications pose challenges, particularly in this era of rising antibiotic resistance. We report a critically ill case with VPS infection due to colistin-resistant that was treated with intraventricular tigecycline as salvage therapy without adverse events, resulting in microbiologic cure and clinical response. The use of intraventricular tigecycline in the treatment of colistin-resistant appears promising; however, appropriate dosage adjustments and evidence-based recommendations are needed.