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脑室内替加环素治疗由耐黏菌素的大肠埃希菌引起的脑室腹腔分流相关感染性休克：一例报告

Intraventricular Tigecycline Therapy for Ventriculoperitoneal Shunt-Related Septic Shock Caused by Colistin-Resistant : A Case Report.

作者信息

Yanık-Yalçın Tuğba, Yeşiler Fatma İrem, Şahintürk Helin, Gülşen Salih, Kurt-Azap Özlem, Zeyneloğlu Pınar

机构信息

Department of Infectious Diseases and Clinical Microbiology, Başkent University School of Medicine, Ankara, Türkiye.

Department of Anesthesiology and Critical Care Unit, Başkent University School of Medicine, Ankara, Türkiye.

出版信息

Infect Dis Clin Microbiol. 2024 Dec 19;6(4):328-333. doi: 10.36519/idcm.2024.384. eCollection 2024 Dec.

DOI:10.36519/idcm.2024.384
PMID:39744665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11687230/
Abstract

Ventriculoperitoneal shunts (VPSs) have been proven to be life-saving procedures, but their complications pose challenges, particularly in this era of rising antibiotic resistance. We report a critically ill case with VPS infection due to colistin-resistant that was treated with intraventricular tigecycline as salvage therapy without adverse events, resulting in microbiologic cure and clinical response. The use of intraventricular tigecycline in the treatment of colistin-resistant appears promising; however, appropriate dosage adjustments and evidence-based recommendations are needed.

摘要

脑室腹腔分流术（VPS）已被证明是挽救生命的手术，但它们的并发症带来了挑战，尤其是在抗生素耐药性不断上升的这个时代。我们报告了一例因对黏菌素耐药而发生VPS感染的危重症病例，该病例接受了脑室内替加环素作为挽救治疗，未出现不良事件，实现了微生物学治愈和临床缓解。脑室内使用替加环素治疗对黏菌素耐药的[此处原文可能有缺失内容]似乎很有前景；然而，需要进行适当的剂量调整并给出基于证据的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/11687230/bb5322097950/IDCM-6-4-384_Figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/11687230/7d9c82aedacc/IDCM-6-4-384_Figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/11687230/bb5322097950/IDCM-6-4-384_Figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/11687230/7d9c82aedacc/IDCM-6-4-384_Figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c1/11687230/bb5322097950/IDCM-6-4-384_Figure2.jpg

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本文引用的文献

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CNS Neurosci Ther. 2023 Mar;29(3):804-815. doi: 10.1111/cns.14086. Epub 2023 Jan 17.
2
The Rapid Emergence of Ceftazidime-Avibactam Resistance Mediated by KPC Variants in Carbapenem-Resistant in Zhejiang Province, China.中国浙江省耐碳青霉烯类肺炎克雷伯菌中由KPC变体介导的头孢他啶-阿维巴坦耐药性的快速出现
Antibiotics (Basel). 2022 May 30;11(6):731. doi: 10.3390/antibiotics11060731.
3
Intraventricular Plus Systemic Antibiotic Therapy for Treating Polymyxin-Resistant Ventriculitis: A Case Report.
脑室内联合全身抗生素治疗多粘菌素耐药性脑室炎：病例报告
Open Forum Infect Dis. 2022 Feb 15;9(4):ofac084. doi: 10.1093/ofid/ofac084. eCollection 2022 Apr.
4
Resistance to ceftazidime/avibactam in infections and colonisations by KPC-producing Enterobacterales: a systematic review of observational clinical studies.产碳青霉烯酶肠杆菌科细菌引起的感染和定植中对头孢他啶/阿维巴坦的耐药性：观察性临床研究的系统评价。
J Glob Antimicrob Resist. 2021 Jun;25:268-281. doi: 10.1016/j.jgar.2021.04.001. Epub 2021 Apr 23.
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Intrathecal Antibacterial and Antifungal Therapies.鞘内抗菌和抗真菌治疗。
Clin Microbiol Rev. 2020 Apr 29;33(3). doi: 10.1128/CMR.00190-19. Print 2020 Jun 17.
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In-vitro activities of imipenem-colistin, imipenem-tigecycline, and tigecycline-colistin combinations against carbapenem-resistant Enterobacteriaceae.亚胺培南-黏菌素、亚胺培南-替加环素及替加环素-黏菌素联合用药对耐碳青霉烯类肠杆菌科细菌的体外活性
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