Fitzgerald Alyson H, Zhang Yuntao, Stewart Samuel, Fritz Scott A, Lynch Alex M, Ramras Monique, Meola Stacy D
Department of Emergency and Critical Care, Wheat Ridge Animal Hospital, Wheat Ridge, CO, United States.
Veterinary Diagnostic Lab, Kansas State University College of Veterinary Medicine, Manhattan, KS, United States.
Front Vet Sci. 2024 Dec 18;11:1516181. doi: 10.3389/fvets.2024.1516181. eCollection 2024.
Alongside the United States' growing landscape of legalized recreational marijuana intended for humans, cases of canine marijuana toxicosis have been on the rise. Most commonly these dogs have mild clinical signs and respond well to supportive therapies. However, patients might still be ataxic, unable to walk, or remain heavily sedated at the time of discharge. Our hypothesis was that flumazenil would improve the level of consciousness, brainstem reflexes, gait, and stance in dogs with marijuana toxicosis.
Seventeen dogs presenting for marijuana toxicosis were enrolled. MGCS and Canine Marijuana Severity Score (CMSS), were used to assess level of consciousness, brain stem reflexes, gait, and stance. Flumazenil 0.01 mg/kg was administered IV once. Baseline values immediately before flumazenil administration, 5 min, 15 min, and 30 min after flumazenil were recorded. Serum was collected and analyzed for delta-9-THC using ultraperformance liquid chromatography.
There was a significant change in MGCS and CMSS following flumazenil administration ( = 0.0033 and ≤ 0.001). The median CMSS at baseline was 17 (10-19), at 5 min was 18 (10-21), at 15 min was 18 (12-22), and at 30 min was 19 (14-22). There was a significant difference between the concentration of delta-9-THC and clinical sign score ( = 0.0275).
The administration of flumazenil to dog affected by marijuana toxicosis might result in improved gait, stance, and level of consciousness. There might be some discriminative ability of the CMSS to stratify the severity level of canine marijuana toxicosis.
在美国，供人类使用的休闲大麻合法化的情况日益增多，与此同时，犬类大麻中毒的病例也在增加。这些狗最常见的症状是临床症状较轻，对支持性治疗反应良好。然而，患者在出院时可能仍然共济失调、无法行走或仍处于深度镇静状态。我们的假设是，氟马西尼可以改善大麻中毒犬的意识水平、脑干反射、步态和姿势。
纳入17只出现大麻中毒症状的犬。采用改良格拉斯哥昏迷评分（MGCS）和犬类大麻严重程度评分（CMSS）来评估意识水平、脑干反射、步态和姿势。静脉注射0.01mg/kg氟马西尼一次。记录氟马西尼给药前、给药后5分钟、15分钟和30分钟的基线值。采集血清，采用超高效液相色谱法分析其中的Δ⁹-四氢大麻酚（delta-9-THC）。
氟马西尼给药后，MGCS和CMSS有显著变化（P = 0.0033和P≤0.001）。基线时CMSS的中位数为17（10 - 19），5分钟时为18（10 - 21），15分钟时为18（12 - 22），30分钟时为19（14 - 22）。Δ⁹-四氢大麻酚浓度与临床症状评分之间存在显著差异（P = 0.0275）。
给受大麻中毒影响的犬使用氟马西尼可能会改善其步态、姿势和意识水平。CMSS可能具有一定的区分犬类大麻中毒严重程度的能力。
