原发性骨髓纤维化进展：一场细胞传话游戏。 - Suppr

Primary myelofibrosis progression: a game of cellular telephone.

作者信息

Wadley Lucas, Fleischman Angela

机构信息

Department of Biological Chemistry.

Department of Biological Chemistry; Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA.

出版信息

Haematologica. 2025 Apr 1;110(4):822-824. doi: 10.3324/haematol.2024.286665. Epub 2025 Jan 2.

DOI:10.3324/haematol.2024.286665

PMID:39744819

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11959259/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc4a/11959259/8112e3c503c3/110822.fig1.jpg

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Primary myelofibrosis progression: a game of cellular telephone.原发性骨髓纤维化进展：一场细胞传话游戏。

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Myeloid neoplasms with features intermediate between primary myelofibrosis and chronic myelomonocytic leukemia.骨髓增生性肿瘤伴原发性骨髓纤维化和慢性粒单核细胞白血病之间特征的肿瘤。

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TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche.TGF-β 信号在骨髓增殖性肿瘤中的作用导致骨髓纤维化，而不破坏造血龛。

J Clin Invest. 2022 Jun 1;132(11). doi: 10.1172/JCI154092.

Transcriptome research identifies four hub genes related to primary myelofibrosis: a holistic research by weighted gene co-expression network analysis.转录组研究鉴定出与原发性骨髓纤维化相关的四个枢纽基因：基于加权基因共表达网络分析的整体研究。

Aging (Albany NY). 2021 Oct 11;13(19):23284-23307. doi: 10.18632/aging.203619.

Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.单细胞分析揭示骨髓纤维化中巨核细胞偏向性造血并鉴定突变克隆特异性靶点。

Mol Cell. 2020 May 7;78(3):477-492.e8. doi: 10.1016/j.molcel.2020.04.008.

Current treatment algorithm for the management of patients with myelofibrosis, JAK inhibitors, and beyond.现行的骨髓纤维化患者管理治疗算法、JAK 抑制剂及其他。

Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):489-497. doi: 10.1182/asheducation-2017.1.489.

Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis.2016 年 WHO 诊断的前纤维化和显性原发性骨髓纤维化患者的表现和转归。

Blood. 2017 Jun 15;129(24):3227-3236. doi: 10.1182/blood-2017-01-761999. Epub 2017 Mar 28.

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。

Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.

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Primary myelofibrosis progression: a game of cellular telephone.

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