Strieter Robert M, Gomperts Brigitte N, Keane Michael P
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
J Clin Invest. 2007 Mar;117(3):549-56. doi: 10.1172/JCI30562.
The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.
CXC趋化因子家族是一类多效性细胞因子家族,参与促进各种白细胞的运输、调节血管生成和血管重塑,以及促进间充质祖细胞(如纤维细胞)的动员和运输。CXC趋化因子的这些功能在肺纤维化和其他纤维增生性疾病的发病机制中具有重要意义。在本综述中,我们讨论CXC趋化因子家族成员的生物学特性,特别是其在调节肺纤维化中血管重塑和循环间充质祖细胞(也称为纤维细胞)运输方面的作用。