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A case series of patients with β-thalassemia trait and iron overload: from multifactorial hepcidin suppression to treatment with mini-phlebotomies.

作者信息

Busti Fabiana, Castagna Annalisa, Marchi Giacomo, Vianello Alice, Chesini Fabio, Bozzini Claudia, Lima Camila Dos Santos, Martinelli Nicola, Nemeth Elizabeta, Ganz Tomas, Girelli Domenico

机构信息

Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy; Veneto Region Referral Center for Iron Disorders and European Reference Network Center for Rare Hematological Diseases "EuroBloodNet".

Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

出版信息

Haematologica. 2025 May 1;110(5):1226-1231. doi: 10.3324/haematol.2024.286413. Epub 2025 Jan 2.

DOI:10.3324/haematol.2024.286413
PMID:39744829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12050917/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e790/12050917/c749e9635ba5/1101226.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e790/12050917/8e8967ee7b30/1101226.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e790/12050917/c749e9635ba5/1101226.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e790/12050917/8e8967ee7b30/1101226.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e790/12050917/c749e9635ba5/1101226.fig2.jpg

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本文引用的文献

1
Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice.铁螯合作用可改善骨髓增生异常综合征小鼠无效造血和铁过载。
Elife. 2023 Dec 28;12:e83103. doi: 10.7554/eLife.83103.
2
Novel potential therapeutics to modify iron metabolism and red cell synthesis in diseases associated with defective erythropoiesis.新型潜在治疗药物可调节与红细胞生成缺陷相关疾病的铁代谢和红细胞生成。
Haematologica. 2023 Oct 1;108(10):2582-2593. doi: 10.3324/haematol.2023.283057.
3
Consensus Statement on the definition and classification of metabolic hyperferritinaemia.
代谢性铁蛋白血症定义和分类的共识声明。
Nat Rev Endocrinol. 2023 May;19(5):299-310. doi: 10.1038/s41574-023-00807-6. Epub 2023 Feb 17.
4
Hepcidin and Iron in Health and Disease.《健康与疾病中的铁调素与铁》
Annu Rev Med. 2023 Jan 27;74:261-277. doi: 10.1146/annurev-med-043021-032816. Epub 2022 Jul 29.
5
β-Thalassemias.β地中海贫血
N Engl J Med. 2021 Feb 25;384(8):727-743. doi: 10.1056/NEJMra2021838.
6
Erythroferrone inhibits the induction of hepcidin by BMP6.促红细胞生成素抑制 BMP6 诱导的铁调素表达。
Blood. 2018 Oct 4;132(14):1473-1477. doi: 10.1182/blood-2018-06-857995. Epub 2018 Aug 10.
7
Immunoassay for human serum erythroferrone.人血清红细胞铁调素免疫测定法
Blood. 2017 Sep 7;130(10):1243-1246. doi: 10.1182/blood-2017-04-777987. Epub 2017 Jul 24.
8
Identification of new BMP6 pro-peptide mutations in patients with iron overload.鉴定铁过载患者中新型 BMP6 前肽突变。
Am J Hematol. 2017 Jun;92(6):562-568. doi: 10.1002/ajh.24730. Epub 2017 Apr 29.
9
Effect of the Hemochromatosis Mutations on Iron Overload among the Indian β Thalassemia Carriers.血色素沉着症突变对印度β地中海贫血携带者铁过载的影响。
J Clin Lab Anal. 2017 May;31(3). doi: 10.1002/jcla.22054. Epub 2016 Aug 26.
10
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Blood. 2016 Jun 9;127(23):2809-13. doi: 10.1182/blood-2015-12-639112. Epub 2016 Apr 4.