Dubois E, Geelen R, Leupe H, Deroose C M, Verslype C
Department of Gastroenterology and Hepatology, AZ Vesalius, Tongeren, Belgium.
Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Acta Gastroenterol Belg. 2024 Oct-Dec;87(4):517-520. doi: 10.51821/87.4.13105.
Small intestinal neuroendocrine tumors (SI-NETs) typically follow an indolent disease course and are often accompanied by mesenteric lymph node metastases upon diagnosis. These tumors can incite a fibroblastic reaction within the mesenteric root. Here, we present two cases of patients with symptomatic small bowel obstruction due to such mesenteric involvement. These patients underwent peptide receptor radionuclide therapy (PRRT), resulting in the stabilization of the mesenteric mass and remarkable improvements in obstructive symptoms. They experienced a return to oral intake and were able to discontinue parenteral nutrition. Despite some controversies, PRRT emerges as a promising tool in managing the mesenteric mass and achieving a reversal of debilitating complications such as obstruction and mesenteric ischemia.
小肠神经内分泌肿瘤（SI-NETs）通常病程进展缓慢，诊断时常常伴有肠系膜淋巴结转移。这些肿瘤可在肠系膜根部引发成纤维细胞反应。在此，我们报告两例因这种肠系膜受累导致症状性小肠梗阻的患者。这些患者接受了肽受体放射性核素治疗（PRRT），结果肠系膜肿块稳定，梗阻症状显著改善。他们恢复了经口进食，能够停止肠外营养。尽管存在一些争议，但PRRT已成为管理肠系膜肿块以及逆转诸如梗阻和肠系膜缺血等使人衰弱的并发症的一种有前景的工具。
