Shabil Muhammed, Bushi Ganesh, Apostolopoulos Vasso, Alrahbeni Tahani, Al-Mugheed Khalid, Khatib Mahalaqua Nazli, Gaidhane Shilpa, Zahiruddin Quazi Syed, Kukreti Neelima, Rustagi Sarvesh, Alhashem Yousef N, Alotaibi Jawaher, Kaabi Nawal A Al, Sulaiman Tarek, Alturaifi Hussain R, Khamis Faryal, Rabaan Ali A, Satapathy Prakasini
University Center for Research and Development, Chandigarh University, Mohali, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Expert Rev Anti Infect Ther. 2025 Jan;23(1):105-118. doi: 10.1080/14787210.2024.2448721. Epub 2025 Jan 4.
Dengue fever is a significant health concern globally, especially in tropical regions. Identifying reliable markers for severe dengue, such as hypoalbuminemia, is crucial for early diagnosis and treatment.
This review systematically explores the association between hypoalbuminemia and severe dengue. We searched databases including PubMed, Embase, Scopus, Cochrane, and Web of Science until 28 December 2023, focusing on studies that reported albumin levels in dengue patients. Our selection criteria aimed at observational studies, from which data extraction and quality assessment were performed using Nested- Knowledge and the Newcastle-Ottawa Scale.
A meta-analysis of 17 studies involving 974 severe and 18,496 non-severe dengue patients identified a standardized mean difference (SMD) in albumin levels of -1.625 g/dL (95% CI: -3.618 to -0.369). Subgroup analysis indicated more pronounced hypoalbuminemia in pediatric patients, with a pooled SMD of -1.08 g/dL (95% CI: -1.71 to -0.45). Our analysis demonstrated the link between hypoalbuminemia and severe dengue, indicating a significant pooled relative risk of 2.286, within 95% CI 1.308 to 3.996.
The study confirms hypoalbuminemia as a significant predictor of severe dengue. Recognizing hypoalbuminemia in dengue patients can aid clinicians in forecasting the severity, potentially improving patient outcomes through targeted therapeutic strategies.
登革热是全球重大的健康问题，在热带地区尤为突出。识别严重登革热的可靠标志物，如低白蛋白血症，对于早期诊断和治疗至关重要。
本综述系统地探讨了低白蛋白血症与严重登革热之间的关联。我们检索了包括PubMed、Embase、Scopus、Cochrane和Web of Science在内的数据库，直至2023年12月28日，重点关注报告登革热患者白蛋白水平的研究。我们的选择标准针对观察性研究，使用嵌套知识和纽卡斯尔-渥太华量表进行数据提取和质量评估。
对17项研究（涉及974例严重登革热患者和18496例非严重登革热患者）的荟萃分析确定，白蛋白水平的标准化平均差（SMD）为-1.625 g/dL（95%置信区间：-3.618至-0.369）。亚组分析表明，儿科患者的低白蛋白血症更为明显，合并SMD为-1.08 g/dL（95%置信区间：-1.71至-0.45）。我们的分析证明了低白蛋白血症与严重登革热之间的联系，表明合并相对风险显著为2.286，在95%置信区间1.308至3.996范围内。
该研究证实低白蛋白血症是严重登革热的重要预测指标。认识到登革热患者的低白蛋白血症可帮助临床医生预测病情严重程度，通过有针对性的治疗策略可能改善患者预后。
