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3
Early Switch From Intravenous to Oral Antibiotics for Patients With Uncomplicated Gram-Negative Bacteremia.早期将静脉内抗生素转换为口服抗生素治疗无并发症革兰氏阴性菌血症患者。
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Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections.革兰氏阴性菌血流感染住院成人患者的口服抗生素治疗转换。
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头孢曲松在预测肠杆菌科分离株对口服高级别头孢菌素的敏感性方面有多准确？

How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?

作者信息

Claeys Kimberly C, Simner Patricia J, Tekle Tsigereda, Harris Anthony D, Jacobs Emily, Cosgrove Sara E, Tamma Pranita D

机构信息

Department of Pharmacy Science and Health Outcomes Research, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

出版信息

Antimicrob Agents Chemother. 2025 Feb 13;69(2):e0138724. doi: 10.1128/aac.01387-24. Epub 2024 Dec 31.

DOI:10.1128/aac.01387-24
PMID:39745384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11823661/
Abstract

The reliability of ceftriaxone for inferring susceptibility to higher-generation oral cephalosporins is unknown. Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to , isolates susceptible to ceftriaxone.

摘要

头孢曲松用于推断对更高代口服头孢菌素敏感性的可靠性尚不清楚。总体而言，根据对409例来自不同患者的连续肠杆菌科血流分离株的纸片扩散结果，头孢曲松敏感性预测了对头孢呋辛（89%）、头孢地尼（86%）、头孢泊肟（90%）和头孢克肟（94%）的敏感性。当仅限于对头孢曲松敏感的分离株时，对四种口服头孢菌素的敏感率在92%至99%之间。