Bokov Plamen, Dudoignon Benjamin, Delclaux Christophe
Université de Paris-Cité, Assistance Publique-Hopitaux de Paris, Hôpital Robert Debré, Service de Physiologie Pédiatrique-Centre du Sommeil, INSERM NeuroDiderot, Paris, France.
J Clin Sleep Med. 2025 May 1;21(5):931-936. doi: 10.5664/jcsm.11538.
This study presents 2 cases of central sleep apnea syndrome in children, highlighting the utility of assessing ventilatory control stability, particularly loop gain and central chemosensitivity in treatment decision-making. In the first case, elevated loop gain for oxygen correlated with periodic breathing, leading to successful treatment with supplemental oxygen in a 13-year-old male with Prader-Willi-like syndrome. Conversely, in the second case, dealing with a 10-year-old female with tumor in the brainstem-spinal cord junction, reduced loop gain prompted treatment with nocturnal noninvasive ventilation. These findings underscore the potential clinical relevance of loop gain measurement in pediatric central sleep apnea. While further research is needed to validate these findings in larger cohorts, loop gain endotyping shows promise as a tool for personalized treatment selection in pediatric sleep-disordered breathing.
Bokov P, Dudoignon B, Delclaux C. Loop gain and central chemosensitivity assessment as a valuable tool in guiding treatment decisions for central sleep apnea in children. . 2025;21(5):931-936.
本研究报告了2例儿童中枢性睡眠呼吸暂停综合征病例，强调了评估通气控制稳定性，特别是环路增益和中枢化学敏感性在治疗决策中的作用。在第一个病例中，一名患有普拉德-威利样综合征的13岁男性，其氧环路增益升高与周期性呼吸相关，通过补充氧气成功治疗。相反，在第二个病例中，一名10岁女性在脑干-脊髓交界处有肿瘤，环路增益降低促使采用夜间无创通气治疗。这些发现强调了环路增益测量在儿童中枢性睡眠呼吸暂停中的潜在临床意义。虽然需要进一步研究在更大队列中验证这些发现，但环路增益分型有望成为儿童睡眠呼吸障碍个性化治疗选择的工具。
博科夫P、杜多尼翁B、德尔克洛C。环路增益和中枢化学敏感性评估作为指导儿童中枢性睡眠呼吸暂停治疗决策的有价值工具。。2025；21(5):931-936。
