Meira E Cruz Miguel, Gozal David, Salles Cristina, Rocha Isabel, Ettlin Dominik
Sleep Unit. Centro Cardiovascular da Universidade de Lisboa (CCUL@RISE). Lisbon Faculty of Medicine. Lisbon. Portugal; International Center for Clinical Sleep Medicine and Research. Bahiana School of Medicine and Public Health. Salvador. Brazil.
Joan C. Edwards School of Medicine. Marshall University. Huntington. United States of America.
Acta Med Port. 2025 Jan 2;38(1):37-41. doi: 10.20344/amp.22350.
The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial stress in patients seeking care at an orofacial pain clinic. Anonymized data of 1236 patients seeking care at the orofacial pain unit of the University of Zurich were analysed. Prevalence data was estimated for insomnia, sleep disordered breathing/sleep apnea and increased risk of a combination of insomnia and sleep disordered breathing/sleep apnea, both regarding demographics and cardiometabolic risk factors. Psychosocial stress factors acting as additional cardiometabolic risk factors were assessed. Among patients with persistent orofacial pain, increased risk of combination of insomnia and sleep disordered breathing/ sleep apnea was present in 11.5% of cases, and it was likely to increase psychosocial stress as an aditional independent risk factor for cardiometabolic disorder.
失眠、睡眠呼吸障碍与持续性/慢性疼痛机制之间存在交叉途径，这一点已有文献记载。这种并存最终将导致心血管代谢疾病负担加重，而心血管代谢疾病是全球主要死因。本研究旨在评估在口腔面部疼痛诊所就诊患者中，失眠、睡眠呼吸障碍、心血管代谢风险和心理社会压力之间的相互作用。分析了苏黎世大学口腔面部疼痛科1236例就诊患者的匿名数据。针对失眠、睡眠呼吸障碍/睡眠呼吸暂停以及失眠与睡眠呼吸障碍/睡眠呼吸暂停合并症风险增加的情况，估算了患病率数据，涉及人口统计学和心血管代谢风险因素。评估了作为额外心血管代谢风险因素的心理社会压力因素。在持续性口腔面部疼痛患者中，11.5%的病例存在失眠与睡眠呼吸障碍/睡眠呼吸暂停合并症风险增加的情况，并且这可能会增加心理社会压力，成为心血管代谢紊乱的另一个独立风险因素。
