Moghnia Ola H, Al Otaibi Hessah S, Al Haqqan Aisha M, Sokhn Elie S, Pathan Seema S, Abdulaziz Nawar E, Mohammed Habiba Y, Al-Sweih Noura A
Department of Microbiology, College of Medicine, Kuwait University, Kuwait City, Kuwait.
Microbiology Laboratory, Maternity Hospital, Ministry of Health, Kuwait City, Kuwait.
Med Princ Pract. 2025;34(3):250-261. doi: 10.1159/000543368. Epub 2025 Jan 2.
Urinary tract infections (UTIs) are common in neonates. Understanding the changes in the prevalence of common uropathogens is essential for early diagnosis and effective treatment of UTIs. This study aimed to identify etiological agents and determine the local antibiotic susceptibility patterns of uropathogens causing UTIs.
A retrospective cross-sectional descriptive study from January 2017 to December 2022 was conducted on hospitalized neonates at Maternity Hospital, Kuwait. Urine samples from neonates were analyzed to identify isolates, and antimicrobial susceptibility testing was determined using the VITEK® 2 system.
Out of 3,996 urine samples processed, 282 (7%) samples yielded significant bacteriuria, mostly from male 185 (65.6%). Gram-negative isolates were the most common 141 (50%), followed by yeasts 84 (29.8%) and Gram-positive isolates 57 (20.2%). The common uropathogens were Klebsiella pneumoniae 50 (17.7%), followed by Escherichia coli 47 (16.8%), Candida albicans 39 (13.8%), Enterococcus faecalis 34 (12%), and Staphylococcus epidermidis 17 (6%). High resistance rates were observed among Enterobacterales against ampicillin, cephalothin, cefuroxime, cefotaxime, nitrofurantoin, amoxicillin-clavulanic acid, ceftazidime, and trimethoprim-sulfamethoxazole. A total of 28 (56%) K. pneumoniae and 18 (38.3%) E. coli were extended-spectrum beta-lactamase producers.
Gram-negative isolates are considered the predominant causative agents of UTIs in neonates at Maternity Hospital. Reduced antibiotic susceptibility to commonly used antibiotics poses a notable challenge in the clinical management of neonates with UTIs. This study underscores the importance of proactive surveillance in monitoring causative organisms and antibiotic susceptibility in neonates.
尿路感染（UTIs）在新生儿中很常见。了解常见尿路病原体患病率的变化对于UTIs的早期诊断和有效治疗至关重要。本研究旨在确定引起UTIs的病原体并确定当地尿路病原体的抗生素敏感性模式。
对科威特妇产医院2017年1月至2022年12月住院的新生儿进行回顾性横断面描述性研究。对新生儿的尿液样本进行分析以鉴定分离株，并使用VITEK® 2系统进行抗菌药物敏感性测试。
在处理的3996份尿液样本中，282份（7%）样本出现显著菌尿，大多数来自男性185份（65.6%）。革兰氏阴性分离株最常见，为141份（50%），其次是酵母菌84份（29.8%）和革兰氏阳性分离株57份（20.2%）。常见的尿路病原体为肺炎克雷伯菌50份（17.7%），其次是大肠杆菌47份（16.8%）、白色念珠菌39份（13.8%）、粪肠球菌34份（12%）和表皮葡萄球菌17份（6%）。观察到肠杆菌科细菌对氨苄西林、头孢噻吩、头孢呋辛、头孢噻肟、呋喃妥因、阿莫西林-克拉维酸、头孢他啶和甲氧苄啶-磺胺甲恶唑的耐药率较高。共有28份（56%）肺炎克雷伯菌和18份（38.3%）大肠杆菌是超广谱β-内酰胺酶产生菌。
革兰氏阴性分离株被认为是妇产医院新生儿UTIs的主要病原体。对常用抗生素的抗生素敏感性降低在UTIs新生儿的临床管理中构成了显著挑战。本研究强调了主动监测在监测新生儿病原体和抗生素敏感性方面的重要性。
