Case R B, Heller S S, Case N B, Moss A J
N Engl J Med. 1985 Mar 21;312(12):737-41. doi: 10.1056/NEJM198503213121201.
To ascertain the influence of personality factors on the course of coronary artery disease, we measured Type A behavior in 516 patients within two weeks after an acute myocardial infarction, using the Jenkins Activity Survey questionnaire. Over a follow-up period of one to three years, there was no relation between the Type A score and total mortality, cardiac mortality, time to death for nonsurvivors, left ventricular ejection fraction, or duration of the stay in the coronary care unit. These negative findings were not changed by restricting the analyses to men below 61 years of age or by comparing extreme score categories. The contributions of behavioral, demographic, and cardiac physiologic factors to postinfarction mortality were also evaluated by multivariate survivorship analyses. The physiologic factors were the only ones that contributed a significant and independent mortality risk; the Type A score did not enter the survivorship model (relative risk, 0.8; 95 per cent confidence interval, 0.5 to 1.5). Thus, we found no relation between Type A behavior and the long-term outcome of acute myocardial infarction.
为确定人格因素对冠状动脉疾病病程的影响,我们使用詹金斯活动调查问卷,在516例急性心肌梗死后两周内的患者中测量了A型行为。在1至3年的随访期内,A型得分与总死亡率、心脏死亡率、非幸存者的死亡时间、左心室射血分数或冠心病监护病房的住院时间之间均无关联。将分析限制在61岁以下男性或比较极端得分类别,这些阴性结果并未改变。行为、人口统计学和心脏生理因素对心肌梗死后死亡率的影响也通过多变量生存分析进行了评估。生理因素是唯一具有显著且独立死亡风险的因素;A型得分未纳入生存模型(相对风险,0.8;95%置信区间,0.5至1.5)。因此,我们发现A型行为与急性心肌梗死的长期预后之间没有关联。