Yang Fang, Wang Li, Wang Haiping, Zhang Song, Li Yixiang
Medical College, Guangxi University, Nanning 530004, Guangxi, China.
Cancer Institute, School of Medicine, Jianghan University, Wuhan, China.
Photodiagnosis Photodyn Ther. 2025 Apr;52:104464. doi: 10.1016/j.pdpdt.2024.104464. Epub 2025 Jan 1.
Colorectal cancer (CRC) is one of the major cancers threatening human health, with high mortality, tumor drug resistance and metastasis. Due to its advantages of non-invasive, strongly targeted and limited side effects, Photodynamic therapy (PDT) has become a promising treatment for CRC. Remarkably, PDT has been shown to activate T cell-adaptive immune response and induce immunogenic cell death (ICD). Used in combination with other treatment techniques, PDT has considerable promise in the management of colorectal cancer. In particular, the combination of PDT and tumor immunotherapy, the systemic anti-tumor immune response was enhanced more significantly. This strategy is expected to achieve a synergistic anti-tumor effect by inducing tumor cell apoptosis, regulating tumor immune microenvironment and effectively activating anti-tumor immunity during treatment process. This review focuses on the research of PDT combined with immunotherapy to improve the treatment of CRC. In most studies, a positive effect was observed for combination therapy, experimentally indicating new therapeutic opportunities for CRC.
结直肠癌（CRC）是威胁人类健康的主要癌症之一，具有高死亡率、肿瘤耐药性和转移特性。由于光动力疗法（PDT）具有非侵入性、强靶向性和副作用有限等优点，已成为一种有前景的CRC治疗方法。值得注意的是，PDT已被证明可激活T细胞适应性免疫反应并诱导免疫原性细胞死亡（ICD）。与其他治疗技术联合使用时，PDT在结直肠癌的治疗中具有相当大的前景。特别是，PDT与肿瘤免疫疗法联合使用时，全身抗肿瘤免疫反应得到更显著增强。该策略有望通过诱导肿瘤细胞凋亡、调节肿瘤免疫微环境以及在治疗过程中有效激活抗肿瘤免疫力来实现协同抗肿瘤效果。本综述重点关注PDT联合免疫疗法改善CRC治疗的研究。在大多数研究中，联合治疗观察到了积极效果，实验表明为CRC提供了新的治疗机会。
